肿瘤相关血栓形成机制及与中性粒细胞外诱捕网关系的研究进展  

Research Progress on the Mechanism of Tumor-associated Thrombosis and Its Relationship with Neutrophil Extrin-sic Trapping Net

作　　者：廖湘成[1] Liao Xiangcheng(Department of Blood Transfusion,Guangxi Zhuang Autonomous Region People's Hospital,Nanning 530022,Guangxi Zhuang Au-tonomous Region,China)

机构地区：[1]广西壮族自治区人民医院输血科,广西壮族自治区南宁530022

出　　处：《中外医药研究》2023年第33期161-163,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：随着肿瘤的发病率不断增高,恶性肿瘤发病人数剧增,患者机体多处于血液高凝状态,可增加血栓形成风险。肿瘤相关血栓(CAT)形成机制与肿瘤本身的因素相关,还与肿瘤的治疗有一定关系。近年来,研究显示中性粒细胞外诱捕网(NETs)在静脉血栓形成中发挥重要作用,NETs不被阿替普酶降解,还可抵抗阿替普酶对血栓诱导溶解的作用。文章主要对CAT的形成机制及与NETs关系的研究进展作一综述。With the increasing incidence of cancer,the number of malignant tumors increases sharply,and the body of patients is mostly in a state of hypercoagulability of blood,which can increase the risk of thrombosis.The formation mechanism of tumor-as-sociated thrombosis(CAT)is related to the factors of the tumor itself,and also to the treatment of the tumor.In recent years,stud-ies have shown that neutrophil extrinsic trapping net(NETs)play an important role in the formation of venous thrombosis.Nets are not degraded by Alteplase and can resist the effect of alteplase on thrombecolysis.Based on this,this article mainly reviewed the formation mechanism of CAT and the research progress of its relationship with NETs.

关 键 词：肿瘤相关血栓 中性粒细胞外诱捕网 机制 相关性 

分 类 号：R73[医药卫生—肿瘤]