Going only half the way:cell cycle exit after the G1 restriction point  

作　　者：Lisa Muller Tony Gutschner Mechthild Hatzfeld 

机构地区：[1]Department of Pathobiochemistry,Institute of Molecular Medicine,Martin Luther University Halle-Wittenberg,Charles Tanford Protein Research Center,Halle,Germany [2]Department of RNA Biology and Pathogenesis,Institute of Molecular Medicine,Martin Luther University Halle-Wittenberg,Charles Tanford Protein Research Center,Halle,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第1期1-2,共2页信号转导与靶向治疗（英文）

基　　金：Open Access funding enabled and organized by Projekt DEAL;supported by the German Research Council(DFG),award numbers HA 1791/11-1-2,HA 1791/12-1 to MH and TG(grant numbers 440716364 and 449501615);financial support of the Open Access Publication Fund of the Martin-Luther-University Halle-Wittenberg.

摘　　要：In a recent article published in Nature,James A.Cornwell et al.describe that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed the G1/restriction(R)-point implicating that the decision is fully reversible(Fig.1).This ground-breaking study could impact future approaches for cancer treatment by targeting the mitotic clock.

关 键 词：point cycle 

分 类 号：R730.5[医药卫生—肿瘤]