Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions  

作　　者：Xiangpeng Sheng Fang Zhu Hong Peng Fan Yang Yi Yang Cong Yang Zhen Wang Wei Chen Deyin Guo Ronggui Hu 

机构地区：[1]State Key Laboratory of Molecular Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai,China [2]MOE Key Laboratory of Tropical Disease Control,Centre for Infection and Immunity Study,School of Medicine,Sun Yat-sen University,Shenzhen,China [3]ICU,Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第1期36-39,共4页信号转导与靶向治疗（英文）

基　　金：funded by the National Science and Technology Innovation 2030 Major Project of China(No.2021ZD0203900);the Ministry of Science and Technology of China(No.2019YFA0802103);the Department of Science and Technology of Zhejiang Province(No.2021C03104);the Guangzhou Science Innovation and Development Program(No.201803010092);the Shenzhen-Hong Kong Institute of Brain Science(No.NYKFKT2019006);the National Natural Science Foundation of China(No.92253302);the Construction Project of Collaborative Response and Intervention Platform for Chinese and Western Medicine(No.ZY2018-2020-FWTX-7004).

摘　　要：Dear Editor,The novel coronavirus SARS-CoV-2 rapidly evolutes to increase its infectivity and transmissibility,facilitates its immune escape,impairs vaccine efficacy,and currently causes repeated infections in human,which is mainly determined by the accumulated mutations in spike(S).1 Transmembrane S is a heavily glycosylated protein on the surface of the virion as homotrimer,responsible for binding to human angiotensin-converting enzyme 2(hACE2)receptor.2 While the architecture of S trimers has been well studied,how the stability of S is regulated by potential host factors remains unknown.

关 键 词：ACE2 VACCINE INFECTION 

分 类 号：R373[医药卫生—病原生物学]