胡椒活性物质胡椒碱通过调节PI3K/AKT改善大鼠运动性骨骼肌损伤  

Piperine in Pepper,Improves Exercise-induced Skeletal Muscle Damage in Rats by Regulating the PI3K/AKT Pathway

作　　者：刘东彪[1] Liu Dongbiao(Guangxi Police College,Nanning,530028)

机构地区：[1]广西警察学院,南宁530028

出　　处：《分子植物育种》2024年第5期1654-1662,共9页Molecular Plant Breeding

基　　金：广西高等教育本科教学改革工程项目(2022JGB415)资助。

摘　　要：随着运动性骨骼肌损伤(EISMD)问题的不断凸显,寻找有效的治疗手段变得尤为迫切。本研究聚焦于胡椒活性物质胡椒碱,这一备受关注的天然化合物因其多重生理活性而引起广泛兴趣。然而,其在EISMD中的确切作用机制尚未充分理解。通过构建EISMD大鼠模型,本研究系统性地探究了胡椒碱的治疗效果,并着重于探讨其是否通过调节PI3K/AKT信号通路来改善EISMD。实验结果显示,胡椒碱处理显著减轻了EISMD大鼠的肌肉损伤,同时在血清水平降低了炎性介质,抑制了氧化应激反应。此外,通过提高ATP含量,胡椒碱促进了细胞能量代谢。深入的机制研究揭示,胡椒碱可能通过激活PI3K/AKT信号通路来抑制细胞凋亡,从而发挥其保护作用。综合而言,胡椒碱展现了多重作用,包括抗炎、抗氧化和抗细胞凋亡,为其作为潜在的EISMD治疗药物提供了实验基础。With the increasing prominence of exercise-induced skeletal muscle damage(EISMD),the search for effective therapeutic interventions becomes urgent.This study focuses on piperine,an active compound in pepper,garnering attention due to its diverse physiological activities.However,the exact mechanism of its action in EISMD remains not fully understood.By establishing an EISMD rat model,this study systematically investigated the therapeutic effects of piperine,with a particular emphasis on exploring whether it improves EISMD by modulating the PI3K/AKT signaling pathway.The experimental results demonstrate that piperine treatment significantly alleviated muscle damage in EISMD rats,concurrently reducing inflammatory mediators in serum and suppressing oxidative stress.Furth ermore,by enhancing ATP levels,piperine facilitated cellular energy metabolism.In-depth mechanistic studies revealed that piperine may exert its protective effects by activating the PI3K/AKT signaling pathway to inhibit cell apoptosis.In summary,piperine exhibits multifaceted actions,including anti-inflammatory,antioxidant,and anti-apoptotic effects,laying an experimental foundation for its potential use as a therapeutic agent for EISMD.

关 键 词：胡椒 胡椒碱 PI3K/AKT信号通路 运动性骨骼肌损伤 细胞凋亡 

分 类 号：TS264.3[轻工技术与工程—发酵工程]