生活方式评分与非酒精性脂肪肝的关联性研究  

Associations of lifestyle scores with nonalcoholic fatty liver disease

作　　者：陈颖[1] 徐柳红 毛盈颖 叶丁 CHEN Ying;XU Liu-hong;MAO Ying-ying;YE Ding(Department of PublicHealth,Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310053,China)

机构地区：[1]浙江中医药大学公共卫生学院,杭州浙江310053

出　　处：《现代预防医学》2024年第4期742-747,共6页Modern Preventive Medicine

摘　　要：目的 基于美国健康与营养调查(NHANES)数据库,探讨生活方式评分与非酒精性脂肪肝(NAFLD)患病之间的关联,为预防和治疗NAFLD提供新思路。方法 本研究基于2007-2018年的美国NHANES人群数据,通过logistic回归分析评估生活方式对NAFLD的影响。进一步通过分层分析,探讨性别、年龄、种族、婚姻状态、教育程度等不同分层之间的差异。结果 本研究共纳入4 105名参与者,其中1 284名NAFLD(24.64%),2 821名非NAFLD(75.36%)。研究发现相较于低生活方式评分,生活方式评分中等(OR=0.372,95%CI:0.25~0.56,P=9.15×10^(-6))和较高(OR=0.091,95%CI:0.06~0.14,P=1.50×10^(-17))的人群发生NAFLD的风险更低。分层分析显示,该效应在男性和60岁以上人群中更强。结论 健康生活方式与较低的NAFLD发生风险有关,通过干预生活方式可以有效防治NAFLD。Objective To analyze and explore the association between lifestyle scores and the risk of developing nonalcoholic fatty liver disease(NAFLD)in the United States(US)population,andto provide new ideas for the prevention and treatment of NAFLD.MethodsT The samples of this study were collected from the 2007-2018 US National Health and Nutrition Examination Survey(NHANES)database.Logistic regression analysis was employed to assess the impact of healthy lifestyle and NAFLD.Further stratified analyses were conducted to investigate potential differences across gender,age,ethnicity,marital status,and education levels.Results A total of 4105 participants were included in this study,comprising 1284 individuals with NAFLD(24.64%)and 2821 individuals without NAFLD(75.36%).Compared to low lifestyle score,individuals with moderate(OR=0.372,95%CI:0.25-0.56,P=9.15×10^(-6))and high lifestyle score(OR=0.091,95%CI:0.06-0.14,P=1.50×10^(-17))had a lower risk of developing NAFLD.Stratified analyses revealed that this effect was more pronounced among males and individuals aged 60 and above.Conclusion Healthy lifestyle is associated with a decreased risk of NAFLD,and improving lifestyle score can be effective in preventing and treating NAFLD.

关 键 词：生活方式评分 非酒精性脂肪肝 NHANES 

分 类 号：R575.5[医药卫生—消化系统]