游离DNA甲基化在非肿瘤性疾病中的应用研究进展  

Research progress in cell free DNA methylation detection technology and its application in non-neoplastic diseases

作　　者：魏丽荣(综述) 杜玉珍(审校) WEI Lirong;DU Yuzhen(Department of Clinical Laboratory,Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 201306,China)

机构地区：[1]上海交通大学医学院附属第六人民医院检验科,上海201306

出　　处：《国际检验医学杂志》2024年第5期635-640,共6页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(81974315);浦东新区科技发展基金事业单位民生科研专项(医疗卫生)项目(PKJ2019-Y05)。

摘　　要：游离DNA已成为新兴的、非侵入性的重要临床样本类型,游离DNA甲基化具有组织特异性,可以反映来源细胞的DNA甲基化状态,在临床疾病诊疗中可能成为重要的潜在标志物。该文旨在综述近年常用的游离DNA甲基化检测技术,以及游离DNA甲基化在神经退行性疾病、精神性疾病、心血管疾病、糖尿病和出生缺陷等非肿瘤疾病中的应用研究进展。Cell-free DNA has emerged as a novel and non-invasive clinical sample type.The methylation patterns of cell-free DNA are tissue-specific and can reflect the DNA methylation status of the source cells.Therefore,they have the potential to serve as important biomarkers in clinical disease diagnosis and treatment.The article aims to review the recent developments in commonly used cell-free DNA methylation detection techniques,as well as the research progress of cell-free DNA methylation in non-neoplastic diseases such as neurodegenerative diseases,psychiatric disorders,cardiovascular diseases,diabetes mellitus,and birth defects.

关 键 词：游离DNA 甲基化 液态活检 非肿瘤性疾病 

分 类 号：R734.2[医药卫生—肿瘤]