肥大细胞与腧穴  

Mast Cells and Acupoints

作　　者：冷三华 景向红[2] 韩松平[3] 王富春[4] 巩昌镇 刘京 郭义[7] 陈波[7] 李灿辉 杨观虎 潘卫星 彭增福 陈德诚 金观源 郭松鹏 刘宏伟 陈大志 苏红 李永明 王少白 朱兵[2] LENG Sanhua;JING Xianghong;HAN Songping;WANG Fuchun;GONG Changzhen;LIU Jing;GUO Yi;CHEN Bo;LI Canhui;YANG Guanhu;PAN Weixing;PENG Zengfu;CHEN Decheng;JIN Guanyuan;GUO Songpeng;LIU Hongwei;CHEN Dazhi;SU Hong;LI Yongming;WANG Shaobai;ZHU Bing(American Traditional Chinese Medicine Society,New York 10016,USA;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;Neuroscience Research Institute,Peking University,Beijing 100191,China;Changchun University of Chinese Medicine,Changchun 130117,Jilin,China;American TCM Association,Roseville 55113,USA;Integra Wellness Health PC,Waltham MA 02452,USA;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Canada TCM Foundation,Toronto M4K 3S5,Canada;Integrative&Optimized Medicine Research Center,China-USA Institute for Acupuncture and Rehabilitation,Wenzhou Medical University,Wenzhou 325027,Zhejiang,China;Howard Hughes Medical Institute,Ashburn 20147,USA;International Trigger Point Center,Hong Kong 999077,China;Natural Acupuncture&Wellness PC,New York 10016,USA;International Institute of Systems Medicine,Milwaukee 53045,USA;Chinatur TCM Praxis Frankenstrasse 3,Luzern CH-6003,Switzerland)

机构地区：[1]美国中医药针灸学会,美国纽约10016 [2]中国中医科学院针灸研究所,中国北京100700 [3]北京大学神经科学研究所,中国北京100191 [4]长春中医药大学,中国长春130117 [5]全美中医药学会,美国罗斯维尔55113 [6]整合医学保健诊所,美国沃尔瑟姆MA02452 [7]天津中医药大学,中国天津301617 [8]加拿大中医基金会,加拿大多伦多M4K3S5 [9]温州医科大学中美针灸康复研究所整合优化医学研究中心,中国温州325027 [10]修斯医学研究所,美国阿什本20147 [11]国际激痛点中心,中国香港999077 [12]美国纽约针灸康复中心,美国纽约10016 [13]美国国际系统医学研究所,美国密尔沃基53045 [14]Chinatur中医诊所,瑞士卢塞恩CH-6003

出　　处：《中华中医药学刊》2024年第1期16-21,共6页Chinese Archives of Traditional Chinese Medicine

摘　　要：皮肤活检发现肥大细胞密集是经脉腧穴和微针系统针刺靶点的共同特点。肥大细胞与神经纤维、微血管在组织分布毗邻。外界机械或温度等物理刺激可激活肥大细胞,释放多种细胞因子和化学因子,形成局部炎症性内环境,导致周围C神经等结构敏化。敏化的C神经释放P物质(SP)、降钙素基因相关肽(CGRP)。SP激活肥大细胞,CGRP促进局部微血管扩张而渗透性增加,血浆外渗,白细胞浸润,促进周围组织敏化。肥大细胞激活与C神经纤维敏化之间的反复循环持久存在会导致中枢敏化。周围与中枢敏化表现为腧穴区域敏化,包括对温度的敏化和对压痛的敏化,成为针刺和艾灸靶组织的重要特征。It is observed that mast cells are enriched in acupoints,meridians and micro-acupuncture system acupoints by skin biopsy.Mast cells,small vessels and nerve fibers are arranged close to each other in tissues near external environments.Physical stimuli such as external mechanical stimuli or temperature can activate mast cells,release various cytokines and chemical factors,form a local inflammatory internal environment and cause sensitization of structures such as the peripheral C nerve.Sensitized C nerve fibers can release substance P that activates mast cells and calcitonin gene related peptide(CGRP),and leads to micro vessels dilation,increased permeability,extravasation of plasma,infiltration of white blood cells,and the promotion of further peripheral sensitization.Persistence in a negative cycle between mast cells activation and C nerve fibers sensitization can eventually cause central sensitization.Peripheral and central sensitizations are manifested as the sensitization of acupoint areas,including changes of temperature and tenderness sensitivities.These changes are characteristics of target tissues of acupuncture and moxibustion.

关 键 词：经脉 腧穴 肥大细胞 C神经纤维 穴位敏化 

分 类 号：R224[医药卫生—中医基础理论]