乳腺癌患者动态对比增强MRI定量参数与病理特征及临床预后的关系  

Relationship Between Quantitative Parameters of Dynamic Contrast-Enhanced MRI and Pathological Features and Clinical Prognosis in Patients with Breast Cancer

作　　者：郑龙 何慕真[2] ZHENG Long;HE Mu-zhen(The Second Hospital of Fuqing,Fujian Fuqing 350300;Provincial Clinical College of Medicine,Fujian Medical University,Fujian Provincial Hospital,Fujian Fuzhou 350001)

机构地区：[1]福清市第二医院,福建福清350300 [2]福建医科大学省立临床医学院,福建省立医院,福建福州350001

出　　处：《中国医疗器械信息》2024年第4期14-16,共3页China Medical Device Information

摘　　要：目的:探讨乳腺癌患者动态对比增强MRI定量参数与病理特征及临床预后的关系。方法:选取2019年3月~2021年3月在本院接受乳腺癌根治术治疗的原发性乳腺癌患者160例作为乳腺癌组,取同期在本院接受乳腺结节切除、术中病理证实为良性的患者100例作为良性对照组,术前均行动态对比增强MRI检查并获取定量参数[速率常数(Kep)、容量转移常数(Ktrans)、血管外细胞外间隙容积比(Ve)]。对比乳腺癌组、良性对照组患者的动态对比增强MRI定量参数值,分析乳腺癌动态对比增强MRI定量参数值与病理特征的关系、乳腺癌动态对比增强MRI定量参数值与预后的关系。结果:乳腺癌组患者的动态对比增强MRI定量参数Kep、Ktrans、Ve值分别高于良性对照组患者,差异均有统计学意义(P<0.05)。乳腺癌患者中,不同分期、淋巴结转移情况、分化程度者的动态对比增强MRI定量参数Kep、Ktrans、Ve值差异有统计学意义(P<0.05)。复发组患者的术前动态对比增强MRI定量参数Kep、Ktrans、Ve值分别高于未复发组患者,差异均有统计学意义(P<0.05)。结论:乳腺癌患者动态对比增强MRI定量参数与病理特征关系密切,且可影响术后复发情况,故术前进行动态对比增强MRI检查可能在乳腺癌病情评估、手术结局预测方面具有肯定作用,是一种可靠的检查手段。Objective:To investigate the relationship between quantitative parameters of dynamic contrast-enhanced MRI and pathological features and clinical prognosis in patients with breast cancer.Methods:160 patients with primary breast cancer who received radical mastectomy in our hospital from March 2019 to March 2021 were selected as the breast cancer group,and 100 patients who received breast nodule resection in our hospital during the same period and were confirmed as benign by intraoperative pathology were selected as the benign control group.Dynamic contrast enhanced MRI was performed before surgery and quantitative parameters[rate constant(Kep),volume transfer constant(Ktrans),extracellular space volume ratio(Ve)]were obtained.Quantitative parameters of dynamic contrast enhanced MRI were compared between patients in the breast cancer group and the benign control group,and the relationship between quantitative parameters of dynamic contrast enhanced MRI and pathological characteristics as well as the relationship between quantitative parameters of dynamic contrast enhanced MRI and prognosis of breast cancer was analyzed.Results:The quantitative parameters Kep,Ktrans and Ve values of dynamic contrast-enhanced MRI in breast cancer group were higher than those in benign control group,the differences were statistically significant(P<0.05).In patients with breast cancer,there were statistically significant differences in Kep,Ktrans and Ve values of dynamic contrast-enhanced MRI quantitative parameters in patients with different stages,lymph node metastasis and differentiation course(P<0.05).The quantitative parameters Kep,Ktrans and Ve values of dynamic contrast enhanced MRI in patients with recurrence before surgery were higher than those in patients without recurrence,with statistical significance(P<0.05).Conclusions:Quantitative parameters of dynamic contrast-enhanced MRI in breast cancer patients are closely related to pathological characteristics,and can affect postoperative recurrence.Therefore,preoperative dynami

关 键 词：乳腺癌 动态对比增强MRI 病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]