HPV-DNA分型检测联合TCT检查用于宫颈癌筛查的临床价值研究  

Clinical Value of HPV-DNA Typing Combined with TCT for Cervical Cancer Screening

作　　者：饶海琴 黄婷 RAO Hai-qin;HUANG Ting(Laboratory Department of Gao’an Maternal and Child Health Hospital,Jiangxi Gao’an 330800;Gynecology Department of Gao’an Maternal and Child Health Hospital,Jiangxi Gao’an 330800)

机构地区：[1]高安市妇幼保健院检验科,江西高安330800 [2]高安市妇幼保健院妇科,江西高安330800

出　　处：《中国医疗器械信息》2024年第4期136-138,共3页China Medical Device Information

摘　　要：目的:探讨人乳头瘤病毒(HPV)-DNA分型检测联合宫颈薄层液基细胞学(TCT)检查用于宫颈癌筛查的临床价值。方法:选择2021年6月~2022年12月本院收治的宫颈病变患者256例,所有入选者均行HPV-DNA分型、TCT。以阴道镜活检为金标准,分析HPV-DNA分型检测、TCT检查单项与联合诊断宫颈癌的价值,并计算一致性。结果:256例宫颈病变患者,经阴道镜检查发现156例阳性,检出率为60.94%。TCT、HPV-DNA联合诊断的灵敏度96.15%、特异度95.00%、准确度95.70%、阳性预测值96.77%、阴性预测值94.06%均高于TCT、HPV-DNA,差异有统计学意义(P<0.05)。TCT、HPV-DNA联合诊断宫颈癌与阴道镜检查结果的一致性优于TCT与HPV-DNA。结论:宫颈癌筛查中使用HPV-DNA分型检测联合TCT检查可提高诊断准确率,为临床诊疗提供更多参考信息。Objective:To explore the clinical value of human papillomavirus(HPV)-DNA typing combined with cervical thin layer liquid based cytology(TCT)for cervical cancer screening.Methods:256 patients with cervical lesions admitted to our hospital from June 2021 to December 2022 were selected,and all participants underwent HPV-DNA typing and TCT.Using colposcopy biopsy as the gold standard,analyze the value of HPV-DNA typing test,TCT examination for single and combined diagnosis of cervical cancer,and calculate consistency.Results:Among the 256 patients with cervical lesions,156 were found to be positive through colposcopy examination,with a detection rate of 60.94%.The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of TCT and HPV-DNA combined diagnosis were 96.15%,95.00%,95.70%,96.77%,and 94.06%,respectively,higher than those of TCT and HPV-DNA,with statistically significant differences(P<0.05).The consistency between the combined diagnosis of cervical cancer with TCT and HPVDNA and the results of colposcopy is better than that of TCT and HPV-DNA.Conclusion:The use of HPV-DNA typing combined with TCT in cervical cancer screening can improve diagnostic accuracy and provide more reference information for clinical diagnosis and treatment.

关 键 词：宫颈癌 HPV-DNA分型 TCT检查 诊断 

分 类 号：R737.33[医药卫生—肿瘤]