基于TCGA数据库分析MEAK7在非小细胞肺癌中的表达和临床意义  

The expression and clinical significance analysis of MEAK7 in non-small cell lung cancer based on TCGA database

作　　者：徐凯丽 吕昕[2] Xu Kaili

机构地区：[1]浙江中医药大学附属衢州中心医院,324000 [2]浙江中医药大学附属第一医院,310006

出　　处：《浙江临床医学》2024年第2期175-177,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探讨MEAK7(MTOR相关蛋白Eak-7同源蛋白)在非小细胞肺癌(NSCLC)中的表达水平与预后的关系,并筛选其靶向结合蛋白及相关基因。方法分析来自TCGA数据库中1,149例NSCLC患者的MEAK7表达数据和临床资料。采用单因素和多因素Cox回归模型评估MEAK7表达水平与临床特征在总生存(OS)和疾病特异生存(DSS)中的影响。同时进行MEAK7的靶向基因和相关基因筛选。结果MEAK7高表达组患者OS和DSS均显著低于低表达组(均P<0.05)。多因素分析显示,MEAK7高表达是NSCLC独立的不良预后因子(OS HR=1.234,P=0.042;DSS HR=1.292,P=0.031)。此外筛选出了一系列MEAK7的靶向结合蛋白和相关基因。结论MEAK7可能是一个新的NSCLC预后标志物。其高表达预示NSCLC患者较差的预后。Objective To investigate the prognostic value of MEAK7 expression and its correlated genes in non-small cell lung cancer(NSCLC).Methods MEAK7 expression data and clinical information of 1149 NSCLC patients were downloaded from The Cancer Genome Atlas(TCGA)database.Univariate and multivariate Cox regression analyses were used to evaluate the association of MEAK7 expression and clinical factors with overall survival(OS)and disease specific survival(DSS).Target genes and correlated genes of MEAK7 were also screened.Results High MEAK7 expression was significantly associated with poor OS and DSS in NSCLC patients(both P<0.05).Multivariate analysis showed that high MEAK7 expression was an independent unfavorable prognostic factor in NSCLC(OS HR=1.234,P=0.042;DSS HR=1.292,P=0.031).Furthermore,a number of MEAK7 target genes and correlated genes were identified.Conclusion MEAK7 may serve as a novel prognostic biomarker in NSCLC.Its upregulation predicts unfavorable survival of NSCLC patients.

关 键 词：非小细胞肺癌 MEAK7 TCGA 预后 

分 类 号：R734.2[医药卫生—肿瘤]