腹腔热灌注化疗对结直肠癌患者术后肠黏膜屏障功能及康复效果影响  

Effect of Intraperitoneal Thermal Perfusion Chemotherapy on Postoperative Intestinal Mucosal Barrier Function and Rehabilitation Outcomes of Patients with Colorectal Cancer

作　　者：林俊双 LIN Junshuang(Department of General Surgery,Yunan County People's Hospital,Yunfu,Guangdong,527199)

机构地区：[1]广东省郁南县人民医院普外科,广东云浮527199

出　　处：《智慧健康》2023年第35期54-57,共4页Smart Healthcare

摘　　要：目的探讨腹腔热灌注化疗对结直肠癌患者术后肠黏膜屏障功能及康复效果影响。方法选取2020年1月—2022年12月本院收治的35例结直肠癌患者为研究对象,按照随机数字表法分为观察组(n=18)和对照组(n=17)。所有患者均行结直肠癌根治术,观察组给予腹腔热灌注化疗,对照组术后则不开展腹腔热灌注化疗。比较两组围手术期相关指标、化疗前后胃肠功能、生存质量水平和术后腹胀发生率。结果与对照组相比较,观察组肠鸣音恢复、首次排气、首次排便时间均较短,差异有统计学意义(P<0.05);术后观察组首次大便性状评分明显低于对照组,差异有统计学意义(P<0.05);观察组术后发生腹胀、恶心呕吐率明显低于对照组,差异有统计学意义(P<0.05);术后两组MTL、GAS水平降低,ORTC QLQ-C30评分提升,且与对照组相比较,观察组MTL、GAS水平下降幅度较小,ORTC QLQ-C30评分较高,差异有统计学意义(P<0.05)。结论结直肠癌患者术后应用腹腔热灌注化疗,能有效改善患者的肠黏膜屏障功能,促进胃肠功能的恢复,同时也有利于提高患者生活质量水平。Objective To explore effect of intraperitoneal thermal perfusion chemotherapy on postoperative intestinal mucosal barrier function and rehabilitation outcomes of patients with colorectal cancer.Methods The paper chose 35 colorectal cancer patients admitted to our hospital from January 2020 to December 2022,and divided them into observation group(n=18)and control group(n=17)with random number table method.All cases were treated with radical surgery for colorectal cancer.Observation group was treated with intraperitoneal thermal perfusion chemotherapy,while control group with no intraperitoneal thermal perfusion chemotherapy after surgery.Perioperative related indicators,gastrointestinal function before and after chemotherapy,life quality levels,and incidence of postoperative abdominal distension were compared between two groups.Results Observation group had shorter recovery times for bowel sounds,first exhaust,and first defecation than control group(P<0.05).Initial stool trait scores in postoperative observation group were(1.13±0.16)points,significantly lower than(2.78±0.41)points in control group(P<0.05).Incidence of postoperative abdominal distension,nausea and vomiting in observation group was both 5.55%,significantly lower than 41.17%and 35.29%in control group(P<0.05).After surgery,MTL and GAS levels decreased in both groups,and ORTC QLQ-C30 scores improved.Observation group had less decrease in MTL and GAS levels,while ORTC QLQ-C30 scores were higher than control group(P<0.05).Conclusion Postoperative intraperitoneal thermal perfusion chemotherapy can effectively improve intestinal mucosal barrier function,promote recovery of gastrointestinal function,and contribute to improving life quality of patients with colorectal cancer.

关 键 词：结直肠癌 腹腔热灌注化疗 手术 肠黏膜屏障功能 康复效果 

分 类 号：R735.34[医药卫生—肿瘤]