白细胞介素-17A(rs2275913)基因多态性与牙周炎易感性的系统评价和meta分析  

Interleukin-17A(rs2275913)gene polymorphism and susceptibility to periodontitis:a systematic review and metaanalysis

作　　者：王瑞[1] 李晨曦[2] 李一鸣 孙家琳 WANG Rui;LI Chenxi;LI Yiming;SUN Jialin(Department of Periodontics,the First Affiliated Hospital/Affiliated Stomatological Hospital of Xinjiang Medical University,Urumqi 830054)

机构地区：[1]新疆医科大学第一附属医院(附属口腔医院)口腔修复种植科,乌鲁木齐830054 [2]新疆医科大学第一附属医院(附属口腔医院)口腔颌面肿瘤外科,新疆维吾尔自治区口腔医学研究所,乌鲁木齐830054 [3]新疆医科大学第一附属医院(附属口腔医院)牙周病科,乌鲁木齐830054 [4]华中科技大学同济医学院公共卫生学院

出　　处：《现代口腔医学杂志》2024年第1期23-29,共7页Journal of Modern Stomatology

基　　金：口腔颌面发育与再生湖北省重点实验室开放课题(2022kqhm008);新疆维吾尔自治区科研创新项目(XJ2023G174)。

摘　　要：目的通过meta分析系统评价白细胞介素(interleukin,IL)-17A(rs2275913)基因多态性与牙周炎易感性风险之间的相关性。方法系统检索截至2022年10月30日发表的关于IL‐17A(rs2275913)基因多态性与牙周炎(periodontitis,PD)关系的病例对照研究,检索的数据库包括中国知网(China National Knowledge Infrastructure,CNKI)、万方、PubMed、Cochrane Library和Embase数据库。通过计算优势比(odds ratios,OR)和95%置信区间(confidence intervals,CI)评估二者相关性。使用纽卡斯尔-渥太华量表(Newcastle-Ottawa scale,NOS)评估纳入文献的质量。应用STATA 12.0软件定量计算所有纳入文献的综合效应,并对结果进行敏感性分析。结果本次meta分析共纳入9项关于IL‐17A(rs2275913)基因多态性和PD易感性的病例对照研究,包括1051例病例和815名对照受试者。总体结果显示,在4种基因模型中IL-17A rs2275913多态性与PD患病风险之间无显著相关性(G versus A:OR=0.78,95%CI:0.55~1.07;GG+GA vs.AA:OR=0.70,95%CI:0.65~1.06;GG vs.GA+AA:OR=1.77,95%CI:0.45~1.10;GG vs.AA:OR=0.61,95%CI:0.34~1.08)。此外,当按照种族、对照来源、基因分布是否符合Hardy-Weinberg平衡(HWE)而进行亚组分析时,结果发现高加索人群和亚洲人群的IL-17A rs2275913多态性对PD发病风险显著增加。在IL-17A rs2275913基因型分布符合HWE的研究中,IL-17A rs2275913与牙周炎易感性具有显著相关性。敏感性分析表明,放弃任何一项研究都不会影响该合并分析结果。结论IL-17A rs2275913基因多态性与人类牙周炎的发病几率并无关联,但在高加索和亚洲患者之间却具有重要关联。受纳入的样本规模和内容影响,这些结果还需要通过更多的工作得到证实。Objective To evaluate the relationship between interleukin(IL)-17A(rs2275913)gene polymorphism and periodontitis susceptibility by meta-analysis.Methods We manually searched the case-control studies on the relationship between IL-17A(rs2275913)gene polymorphism and periodontitis(PD)published by October 30th,2022.The databases manually searched include China National Knowledge Infrastructure(CNKI),Wanfang,PubMed,Cochrane Library and Embase databases.The correlation was evaluated by calculating 95%confidence intervals(CI)and odds ratios(OR).The Newcastle-Ottawa scale(NOS)tool was used to assess the quality of the included literature.STATA 12.0 application software was used to quantitatively synthesize the comprehensive effect of all included literatures and to conduct sensitivity analysis based on the results.Results Our meta-analysis included nine case-control studies with 1051 cases and 815 control subjects.Meta-analysis results showed that there was no significant correlation between IL-17A rs2275913 polymorphism and risk of PD in four IL-17A(rs2275913)gene polymorphisms and periodontitis susceptibility models(G versus A:OR=0.78,95%CI:0.55~1.07;GG+GA vs.AA:OR=0.70,95%CI:0.65-1.06;GG vs.GA+AA:OR=1.77,95%CI:0.45~1.10;GG vs.AA:OR=0.61,95%CI:0.34~1.08).In addition,when subgroup analysis was conducted according to race,control source,and gene distribution in accordance with Hardy-Weinberg equilibrium(HWE),it showed that the risk of PD in Caucasian and Asian populations had statistically significant increase.In the study that the distribution of IL-17A rs2275913 genotype is consistent with HWE,IL-17A rs2275913 has a significant correlation with periodontitis susceptibility.Sensitivity analysis showed that abandoning any study would not affect the results of combined analysis.Conclusion The IL-17A rs2275913 gene polymorphism is not associated with the incidence of human periodontitis,but it has an important association between Caucasian and Asian patients.Affected by the sample size and research content of eligible stu

关 键 词：牙周炎 基因多态性 人白细胞介素-17(rs2275913) META分析 

分 类 号：R781.4[医药卫生—口腔医学]