人格特质、心理弹性、应对方式对舍曲林治疗女性青少年首发抑郁障碍效果的影响  

Influence of personality traits,resilience and coping style on the efficacy of sertraline treatment in female adolescents with first-episode depressive disorder

作　　者：黄乾坤 舒燕萍 岳雅 Huang Qiankun;Shu Yanping;Yue Ya(Yichang Mental Health Center,Institute of Mental Health,Three Gorges University,Yichang 443000,China;Guizhou Second People's Hospital,Guiyang 550000,China)

机构地区：[1]宜昌市精神卫生中心,三峡大学精神卫生研究所,湖北宜昌443000 [2]贵州省第二人民医院,贵州贵阳550000

出　　处：《四川精神卫生》2024年第1期33-38,共6页Sichuan Mental Health

基　　金：2019年度贵阳市科技计划项目(项目名称:贵州省青少年抑郁症精准诊疗科技创新平台,项目编号:筑科合同[2019]9-3-1号)。

摘　　要：背景青少年抑郁障碍患病率较高,女性患病率高于男性,且女性的抑郁症状更重。舍曲林常用于青少年抑郁障碍治疗,但仅部分患者有效,目前对女性青少年抑郁障碍患者使用舍曲林治疗效果进行预测的研究有限。目的探讨人格特质、心理弹性、应对方式与女性青少年首发抑郁障碍患者使用舍曲林治疗效果的关系,以期为女性青少年首发抑郁障碍的治疗提供参考。方法选取2019年2月—2021年1月于贵州省第二人民医院就诊的、符合《国际疾病分类(第10版)》(ICD-10)抑郁障碍诊断标准的112例女性青少年首发抑郁障碍患者为研究对象。患者均接受4周舍曲林治疗。采用大五人格简式量表(NEO-FFI)、青少年心理弹性量表(RSCA)、中学生应对方式量表(CSSMSS)、汉密尔顿焦虑量表(HAMA)以及汉密尔顿抑郁量表17项版(HAMD-17)进行评定。采用Logistic回归分析探讨舍曲林对女性青少年首发抑郁障碍治疗效果的影响因素。结果神经质人格(β=-0.115,95%CI:0.807~0.984)可负向预测舍曲林对女性青少年首发抑郁障碍的治疗效果;宜人性人格(β=0.129,95%CI:1.025~1.264)和RSCA评分(β=0.062,95%CI:1.004~1.128)可正向预测其治疗效果。结论高神经质、低宜人性、低心理弹性可能是舍曲林对女性青少年首发抑郁障碍治疗效果欠佳的危险因素。Background Depressive disorders are prevalence among adolescents,with a higher incidence in females compared to males,often accompanied by more severe depressive symptoms.Sertraline is commonly prescribed for adolescent depressive disorder,however,its efficacy is only evident in certain patients.Currently,there is limited research on predicting the therapeutic efficacy of sertraline in female adolescents with depressive disorder.Objective To explore the relationship between personality traits,psychological resilience,coping style and the clinical efficacy of sertraline treatment in female adolescents with first-episode depressive disorder,in order to provide references for the treatment of this population.Methods A total of 112 female adolescent patients with first-episode depressive disorder,meeting the diagnostic criteria of the International Classification of Diseases(tenth edition)(ICD-10),and undergoing a 4-week treatment regimen with sertraline,were selected from the Second People's Hospital of Guizhou Province from February 2019 to January 2021.General demographic questionnaire,NEO Five-Factor Inventory(NEO-FFI),Resilience Scale for Chinese Adolescents(RSCA),Coping Style Scale for Middle School Students(CSSMSS),Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale-17 item(HAMD-17)were used for assessment.Logistic regression analysis was used to investigate the factors influencing the clinical efficacy of sertraline in the treatment of female adolescents with first-episode depressive disorder.Results Neuroticism(β=-0.115,95%CI:0.807~0.984)could negatively predicted the therapeutic efficacy of sertraline in female adolescents with first-episode depressive disorder,whereas agreeableness(β=0.129,95%CI:1.025~1.264)and RSCA score(β=0.062,95%CI:1.004~1.128)could positively predict its therapeutic efficacy.Conclusion High neuroticism,low agreeableness and low psychological resilience may be the risk factors for the poor therapeutic effect of sertraline in the treatment of female adolescents with first-episo

关 键 词：女性 青少年 抑郁障碍 人格特质 心理弹性 应对方式 

分 类 号：R749.4[医药卫生—神经病学与精神病学]