SF-36量表评估中国中部地区脑萎缩人群的效果  

Evaluation of Screening the Population with Brain Atrophy inCentral China by Using the SF-36 Scale

作　　者：杨立新 貌志成 姚家桢 洪强 黄海营 胡海 YANG Lixin;MAO Zhicheng;YAO Jiazhen;HONG Qiang;HUANG Haiying;HU Hai(First Affiliated Hospital of Anhui University of Science and Technology,Huainan Anhui 232000,China;Suzhou Medical College,Soochow University,Suzhou Jiangsu 215000,China)

机构地区：[1]安徽理工大学第一附属医院,安徽淮南232000 [2]苏州大学医学院,江苏苏州215000

出　　处：《安徽理工大学学报（自然科学版）》2023年第6期101-108,共8页Journal of Anhui University of Science and Technology:Natural Science

基　　金：安徽省高校自然科学研究项目(KJ2021A0420)。

摘　　要：目的探索脑萎缩影像学改变与SF-36量表之间的关联,探讨SF-36量表应用于脑萎缩患者的价值及其测量脑萎缩患者生命质量的信度和效度,评估SF-36量表评分对脑萎缩的诊断效能。方法随机选取263名居民进行磁共振平扫检查,并利用SF-36量表进行生活质量评测,采用克隆巴赫系数(Cronbach'sα)、ROC曲线分析、Kappa检验分析SF-36量表的信度和诊断效能。单因素分析采用t检验,多因素分析采用Logistic回归分析来筛选生命质量相关因素。结果基于影像学金标准诊断的脑萎缩阳性组和脑萎缩阴性组在年龄、性别的差异具有统计学意义(P<0.05),BMI的构成比无统计学意义(P>0.05);脑萎缩患者SF-36量表中除SF、RE外,其余6各维度和PCS和MCS较中国常模数值均存在显著功能缺陷(P<0.05);SF-36量表总分及8个维度的Cronbach'sα系数均高于0.7,RP、BP、SF、RE 4个维度出现天花板效应,RP、RE这两个维度出现地板效应;Logistic回归分析显示,在未矫正其他变量时,SF-36总分和PCS得分与患脑萎缩的风险显著负相关51~60岁患者和女性患者患脑萎缩的风险显著上升;在调节性别、年龄、BMI等变量后,51~60岁患者和女性患者仍是患脑萎缩的独立危险因素。结论SF-36量表对脑萎缩患者生命质量的测量具有良好的信度和效度以及一定的区别能力,可以用于评价脑萎缩患者的生命质量,并为后续制定评价脑萎缩病情发展、治疗疗效的工具提供一定参考,但对于筛查和预测脑萎缩高风险人群效果不佳。Objective To explore the association between imaging changes of cerebral atrophy and SF-36 scale,evaluate the SF-36 scale applied to patients with cerebral atrophy and its reliability and validity in measuring the quality of life of the patients with cerebral atrophy,and to assess the diagnostic efficacy of SF-36 scale scores for cerebral atrophy.Methods 263 residents were randomly selected to undergo magnetic resonance imaging(MRI)scanning,and the SF-36 scale was used to assess the quality of life.The reliability and diagnostic efficacy of the SF-36 scale were analysed by Cronbach'sα,ROC curve analysis,and Kappa test.The t-test was used for univariate analysis,and the logistic regression analysis was used for multivariate analysis to screen the factors related to the quality of life.Results The differences between the brain atrophy-positive and brain atrophy-negative groups diagnosed on the basis of the imaging gold standard were statistically significant in terms of age and gender(P<0.05),and the constitutive ratios of BMI were not statistically significant(P>0.05).The six dimensions in the SF-36 scale of the patients with brain atrophy,except for SF and RE,and the PCS and MCS had significant functional deficits compared with the values of the Chinese norms(P<0.05).Cronbach's alpha coefficients for the SF-36 scale total score and the eight dimensions were higher than 0.7,and there was a ceiling effect for four dimensions,RP,BP,SF,and RE,and a floor effect for two dimensions,RP and RE.The logistic regression analyses showed that when other variables werer uncorrected,the SF-36 total score and PCS scores were significantly negatively correlated with the risk of developing cerebral atrophy.The risk of developing cerebral atrophy was significantly increased in patients aged 51~60 years and female patients.After adjusting for gender,age,BMI and other variables,patients aged 51~60 years and female patients were still independent risk factors for developing cerebral atrophy.Conclusion The SF-36 scale has a good relia

关 键 词：脑萎缩 SF-36量表 生命质量 

分 类 号：R74[医药卫生—神经病学与精神病学]