肠道微生物参与帕金森病发生发展的研究进展  

Research progress on the involvement of intestinal microbes in the occurrence and development of Parkinson’s disease

作　　者：冯薇[1] FENG Wei(West China Hospital,Sichuan University,Chengdu 610000,China)

机构地区：[1]四川大学华西医院,四川成都610000

出　　处：《中国实用神经疾病杂志》2024年第4期504-507,共4页Chinese Journal of Practical Nervous Diseases

基　　金：成都市医学科研课题(编号:2022350)。

摘　　要：帕金森病是一种由多种因素导致的临床综合征,主要表现为多巴胺能神经元丢失和α-突触核蛋白异常聚集两方面。肠道微生物异常代谢产物可作为炎症因子通过循环途径进入大脑引起线粒体功能障碍,导致多巴胺神经元丢失,也可作为信号因子通过脑-肠-微生物组轴损伤中枢神经系统,并造成α-突触核蛋白错误折叠。本文综述了肠道微生物及其代谢产物在帕金森病中的临床应用和研究进展,以期为帕金森病患者的治疗提供新的思路。Parkinson’s disease(PD)is a clinical syndrome caused by multiple factors,mainly including loss of dopaminergic neurons and abnormal aggregation ofα-synuclein.As inflammatory factors,abnormal metabolites of intestinal microbes can enter the brain through the circulatory pathway to cause mitochondrial dysfunction and loss of dopamine neurons.As signaling factors,the abnormal metabolites can damage central nervous system through brain-gut-microbiome axis(BGMA)to cause misfolding ofα-synuclein.This article reviews the clinical application and research progress of intestinal microbes and their metabolites in Parkinson’s disease in order to provide new treatment ideas for Parkinson’s disease.

关 键 词：帕金森病 肠道微生物 线粒体 脑-肠-微生物组轴 功能障碍 

分 类 号：R742.5[医药卫生—神经病学与精神病学]