^(13)C尿素呼气试验DOB值与上消化道疾病的相关性  

Correlation between^(13)C urea breath test values and upper gastrointestinal disease

作　　者：曹笑寅 年媛媛 孟宪梅[2] 刘琳[2] 王璐[2] 曹豆豆 CAO Xiao-yin;NIAN Yuan-yuan;MENG Xian-mei;LIU Lin;WANG Lu;CAO Dou-dou(Baotou Medical College,Baotou Inner Mongolia 014040;Department of Gastroenterology,the Second Affiliated Hospital of Baotou Medical College 014030,China)

机构地区：[1]内蒙古科技大学包头医学院,014040 [2]内蒙古科技大学包头医学院第二附属医院消化内科,014030

出　　处：《现代消化及介入诊疗》2023年第11期1358-1361,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：公立医院科研联合基金科技项目(2023GLLH0210);内蒙古自治区科技计划项目(2021GG0232);内蒙古自治区高等学校科学研究项目(NJZY22057)。

摘　　要：目的探究^(13)C尿素呼气试验超级准值(^(13)C-UBT DOB值)与上消化道疾病类型及慢性萎缩性胃炎(CAG)胃黏膜病理分级的关系。方法回顾性选取^(13)C-UBT阳性(DOB≥4.0‰)同时完善胃镜检查的596例患者,纳入呈阴性(DOB<4.0‰)诊断为CAG患者25例作为对照,分析DOB值与上消化道疾病类型及CAG胃黏膜病理分级的相关性。结果入组患者中女性DOB值显著高于男性,DOB值与上消化道疾病类型的关系有统计学意义,慢性胃炎、消化性溃疡、胃癌的DOB值呈下降趋势。DOB值与胃黏膜萎缩、肠化程度差异具有统计学意义,中度及以上萎缩、肠化患者,DOB值呈下降趋势;与炎症、炎症活动性程度未见相关性,说明DOB值不能预测疾病及胃黏膜损伤的严重程度,对于低DOB值患者同样需要重视。结论DOB值定量对于临床中推测上消化道疾病、胃黏膜损伤程度有一定价值,但不能作为诊断Hp感染相关疾病及判断胃黏膜损伤程度的依据。Objective To explore the correlation of^(13)C urea breath test values(^(13)C-UBT DOB)with upper gastrointestinal disease type and the pathological grade of gastric mucosa in chronic atrophic gastritis(CAG).Methods A retrospective study was selected of 596 patients who tested positive for^(13)C-UBT(DOB≥4.0‰)and completed gastroscopy as clinical data.25 patients tested negative(DOB<4.0‰)and were diagnosed with CAG as the control group.To analyze whether there is a statistical difference between the DOB values and the type of upper gastrointestinal disease and the pathological grading of CAG gastric mucosa.Results The DOB values of females is significantly higher than that of males in the enrolled patients.There is a statistically significant relationship between the levels of DOB values and the types of upper gastrointestinal diseases,the DOB values of chronic gastritis,peptic ulcer,and gastric cancer showed a decreasing trend.The DOB values is negatively correlated with the degree of gastric mucosal atrophy and intestinal metaplasia,the DOB values were decreasing trend in moderate and above patients with atrophy and enterization;but the DOB values is no correlation with the degree of inflammation and inflammatory activity;this means that the DOB values could not predict the severity of the disease and the gastric mucosal damage,patients with low DOB values also need attention.Conclusion Quantitative DOB have certain value in predicting upper gastrointestinal diseases and gastric mucosal damage in clinical practice,but cannot be used as a basis for diagnosing Hp infection related diseases and determining the degree of gastric mucosal damage.

关 键 词：幽门螺杆菌 ^(13)C尿素呼气试验 超基准值 慢性萎缩性胃炎 

分 类 号：R573[医药卫生—消化系统]