COX-2、G-17、miR-92a表达及幽门螺杆菌感染与结直肠息肉、结直肠癌发生的相关性  

The correlation between the expression of COX-2,G-17,miR-92a,Helicobacter pylori infection,and the occurrence of colorectal polyps and cancer

作　　者：周宁 刘君 杨俐[2] 李韬 苟慧敏 许婷婷 ZHOU Ning;LIU Jun;YANG Li;LI Tao;GOU Hui-min;XU Ting-ting(Department of Pathology,Fourth Hospital,Mianyang,Sichuan 621000,China;Department of Pathology,Santai County People′s Hospital,Santai 621100,China)

机构地区：[1]四川绵阳四○四医院病理科,621000 [2]三台县人民医院病理科,621100

出　　处：《现代消化及介入诊疗》2023年第11期1377-1381,1385,共6页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：中国消化道早癌医师共同成长计划科研项目(GTC2-2020-SC-51-0009);绵阳市卫生健康委医学科研课题(202055)。

摘　　要：目的探讨环氧合酶-2(COX-2)、胃泌素17(G-17)、miR-92a表达及幽门螺杆菌(Hp)感染与结直肠息肉、结直肠癌发生的相关性。方法选取2021年1月至2022年12月在四川绵阳四○四医院就诊的结直肠息肉患者62例(息肉组),结直肠癌患者48例(肿瘤组),检查两组组织COX-2、外周血G-17、粪便miR-92a表达以及幽门螺旋杆菌感染情况,分析其与结直肠息肉、结直肠癌发生的相关性。结果肿瘤组COX-2阳性表达率和Hp感染率分别为68.75%和75.00%,明显高于息肉组(P<0.05);肿瘤组G-17和miR-92a相对表达量分别为(25.56±7.76)pmol/L和(1.94±0.43),明显高于息肉组(P<0.05);息肉最大直径≥10mm患者COX-2阳性表达率、G-17、miR-92a相对表达量和Hp感染率分别为41.94%、(22.42±5.28)pmol/L、(1.29±0.25)和38.71%,明显高于息肉最大直径<10mm患者(P<0.05);息肉多发患者COX-2阳性表达率、G-17、miR-92a相对表达量和Hp感染率分别为45.83%、(23.12±5.14)pmol/L、(1.33±0.23)和54.17%,明显高于息肉单发患者(P<0.05);多发肿瘤患者G-17和miR-92a相对表达量分别为(30.72±6.00)pmol/L和(2.12±0.33),明显高于单发肿瘤患者(P<0.05);TNM分期Ⅲ~Ⅳ期患者COX-2阳性表达率、G-17、miR-92a相对表达量和Hp感染率分别为100.00%、(29.60±6.80)pmol/L、(2.15±0.44)和100.00%,明显高于Ⅰ~Ⅱ期患者(P<0.05);息肉组Hp感染患者COX-2阳性表达率、G-17和miR-92a相对变量分别为56.25%、(23.42±5.65)pmol/L和(1.34±0.21),明显高于无Hp感染患者(P<0.05);肿瘤组Hp感染患者COX-2阳性表达率、G-17和miR-92a相对变量分别为83.33%、(27.12±5.109)pmol/L和(2.12±0.26),明显高于无Hp感染患者(P<0.05)。结论COX-2、G-17、miR-92a表达及Hp感染与结直肠息肉、结直肠癌临床特征有关,同时Hp感染可提高COX-2、G-17、miR-92a表达。Objective To investigate the relationship between the expression of cyclooxygenase-2(COX-2),Gastrin 17(G-17),miR-92a,Helicobacter pylori(Hp)infection and colorectal polyps and cancer.Methods A total of 62 patients with colorectal polyps(polyp group)and 48 patients with colorectal cancer(tumor group)were selected from our hospital from January 2021 to December 2022.The expression of COX-2,peripheral blood G-17 and fecal miR-92a and helicobacter pylori infection in the tissues of the two groups were examined,and their correlation with colorectal polyps and colorectal cancer was analyzed.Results The positive expression rate of COX-2 and Hp infection rate in the tumor group were 68.75%and 75.00%,respectively,which were significantly higher than those in the polyp group(P<0.05).The G-17 and miR-92a relative expression levels in the tumor group were(25.56±7.76)pmol/L and(1.94±0.43),respectively,whichwassignificantly higher than those in the polyp group(P<0.05).The positive expression rate of COX-2,G-17,relative expression levels of miR-92a,and Hp infection rate in patients with a maximum diameter of polyps≥10 mm were 41.94%,(22.42±5.28)pmol/L,(1.29±0.25),and 38.71%,respectively,which were significantly higher than those in patients with a maximum diameter of polyps<10 mm(P<0.05).The positive expression rate of COX-2,G-17,relative expression levels of miR-92a,and Hp infection rate in patients with multiple polyps were 45.83%,(23.12±5.14)pmol/L,(1.33±0.23),and 54.17%,respectively,which were significantly higher than those in patients with single polyps(P<0.05).The G-17 and relative expression levels of miR-92a in patients with multiple tumors were(30.72±6.00)pmol/L and(2.12±0.33),respectively,which were significantly higher than those in patients with single tumors(P<0.05).The positive expression rate of COX-2,G-17,relative expression levels of miR-92a,and Hp infection rate in TNM stageⅢ-Ⅳpatients were 100.00%,(29.60±6.80)pmol/L,(2.15±0.44),and 100.00%,respectively,which were significantly higher than tho

关 键 词：环氧合酶-2 胃泌素17 miR-92a 幽门螺杆菌 结直肠息肉 结直肠癌 

分 类 号：R735.35[医药卫生—肿瘤] R574[医药卫生—临床医学]