原料药减压蒸馏系统的共性问题及解决方案  

Common Problems and Solutions of Vacuum Distillation Systems for Active Pharmaceutical Ingredients

作　　者：曹子英[1] 史大鹏 孙晓波 CAO Ziying;SHI Dapeng;SUN Xiaobo

机构地区：[1]重庆工贸职业技术学院 [2]重庆圣华曦药业股份有限公司 [3]重庆精准生物技术有限公司

出　　处：《化工装备技术》2024年第1期15-18,共4页Chemical Equipment Technology

基　　金：重庆市教委新技术推广项目(GZTG201612)。

摘　　要：深入分析了原有减压蒸馏系统存在问题及产生原因。在减少蒸馏罐和真空泵的前提下,通过合理设计系统的设备配置流程,选购新型换热设备,自制高效分离设备,提高了系统的冷凝(冷却)性能、气液分离性能和管道通量。有效利用真空系统的额定抽气能力,使蒸馏速度数倍提高、蒸馏温度明显下降,进而提高了产品产量、质量和收率。同时,提高溶剂回收率,降低水电汽冷和设备维保费用及人工费用,大幅降低三废排放和后续处理费用,节能减排效果显著。The problems and causes of the original vacuum distillation system were thoroughly analyzed.On the premise of reducing distillation tanks and vacuum pumps,by reasonably designing the equipment configuration process of the system,selecting a new type of heat exchange equipment,and self-made high-efficiency separation equipment,the condensation(cooling)performance,gas-liquid separation performance,and pipeline flux of the system were improved.The rated pumping capacity of the vacuum system was effectively utilized,resulting in several times higher distillation speed and a significant decrease in distillation temperature,thereby improving product yield,quality,and yield.At the same time,the solvent recovery rate was improved,the costs of water,electricity,steam cooling,equipment maintenance,and labor were reduced,and the emissions of three wastes and subsequent treatment costs were significantly reduced,resulting in significant energy-saving and emission reduction effects.

关 键 词：原料药 减压蒸馏 真空 节能减排 

分 类 号：TQ036[化学工程]