脑循环治疗仪联合神经节苷脂治疗小儿脑瘫的临床疗效  

Clinical Efficacy of Brain Circulation Therapy Apparatus Combined with Ganglioside in the Treatment of Children with Cerebral Palsy

作　　者：汪飞 刘雪杰[2] WANG Fei;LIU Xue-jie(Department of Pediatrics,Taiqian County People's Hospital,Puyang 457631,China;Department of Pediatrics,Puyang Oilfield General Hospital,Puyang 457100,China)

机构地区：[1]台前县人民医院儿科,濮阳457631 [2]濮阳市油田总医院儿科,濮阳457100

出　　处：《四川解剖学杂志》2023年第4期28-30,共3页Sichuan Journal of Anatomy

摘　　要：目的:探讨脑循环治疗仪联合神经节苷脂治疗小儿脑瘫的临床疗效.方法:选取2021年1月至2022年10月台前县人民医院收治的68例小儿脑瘫患儿为研究对象.按照随机数字表法将其分为观察组(n=34,采用神经节苷脂治疗联合脑循环治疗仪治疗)和对照组(n=34,仅采用神经节苷脂治疗).两组患儿均治疗10d.比较两组患儿临床疗效、血清肌酸激酶脑型同工酶(CK-BB)水平、血清内皮生长因子(VEGF)水平、肢体运动功能等.结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05).治疗后,观察组血清VEGF和CK-BB水平低于对照组,粗大运动功能测试量表(GMFM)评分高于对照组,改良Ashworth量表(MAS)评分低于对照组,差异均有统计学意义(P<0.05).结论:脑循环治疗仪联合神经节苷脂治疗能够促进小儿脑瘫患儿脑部功能修复,有利于改善患儿的肢体运动功能,值得临床推广应用.Objective:To investigate the clinical effects of cerebral circulation therapy apparatus combined with ganglioside in the treatment of children with cerebral palsy.Methods:A total of 68 children with cerebral palsy admited to Taiqian County People's Hospital from January 2021 to October 2022 were selected in this study.According to the random number table,they were divided into the observation group(n=34,treated with cerebral circulation therapy apparatus combined with ganglioside)and the control group(n=34,treated with ganglioside).And both groups were treated for 10 days.The clinical efficacy,the levels of serum creatine kinase brain isozyme(CK-BB)and serum endothelial growth factor(VEGF),and limb motor function were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,there was statistically significant difference between the two groups(P<O.05).After treatment,the levels of serum VEGF and CK-BB in observation group were lower than those in the control group,the score of gross motor function scale(CMFM)in the observation group was higher than that in the control group,and the score of modified ashworthscale(MAS)in the observation group was lower than that in the control group,there were statistically significant diferences between the two groups(P<0.05).Conclusion:Cerebral circulation therapy apparatus combined with ganglioside therapy can promote the repair of brain function in children with cerebral palsy,and is beneficial to improve the motor function of children's limbs,which is worthy of clinical application.

关 键 词：脑循环治疗仪 神经节苷脂 小儿脑瘫 血管内皮生长因子 肢体运动功能 

分 类 号：R742.3[医药卫生—神经病学与精神病学]