胃混合性腺神经内分泌癌淋巴结转移的临床研究进展  

Clinical research progress on lymph node metastasis in gastric mixed adenoneuroendocrine carcinoma

作　　者：周凯(综述) 王安强(综述) 吴艳(综述) 李忠武(综述)[2] 步召德(审校)[1] Kai Zhou;Anqiang Wang;Yan Wu;Zhongwu Li;Zhaode Bu(Center of Gastrointestinal Cancer,Peking University Cancer Hospital&Institute,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Beijing 100142,China;Department of Pathology,Peking University Cancer Hospital&Institute,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Beijing 100142,China)

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心,恶性肿瘤发病机制及转化研究教育部重点实验室,北京市100142 [2]北京大学肿瘤医院病理科,恶性肿瘤发病机制及转化研究教育部重点实验室

出　　处：《中国肿瘤临床》2023年第24期1275-1279,共5页Chinese Journal of Clinical Oncology

基　　金：首都卫生发展科研专项项目(编号:2022-4-1025)资助。

摘　　要：胃混合性腺神经内分泌癌(gastric mixed adenoneuroendocrine carcinoma,G-MANEC)是一种罕见的胃肠道肿瘤,发病率虽不高但有上升趋势,由于其具有高度侵袭性的生物学行为,且容易发生淋巴转移及远处转移,预后较差,因此备受研究者的关注。其由腺癌和神经内分泌癌两种成分组成,且两者成分占比均不小于30%。近年来,G-MANEC的相关研究不断开展,然而,目前关于G-MANEC的淋巴结转移成分的研究仍有不足且存在亟需解决的问题。本文结合胃癌的研究,系统回顾了既往关于混合性神经内分泌-非神经内分泌肿瘤(mixed neuroendocrine-non-neuroendocrine neoplasms,MiNEN)的病例报道及研究,主要探讨了GMANEC的流行病学、生物学起源、诊断、淋巴结转移模式、淋巴结转移与血行转移、远处转移的关系、治疗,以期为G-MANEC的后续研究提供方向。Gastric mixed adenoneuroendocrine carcinomas(G-MANEC)are an infrequent variant of gastrointestinal tumors.Despite their relatively low occurrence,there has been a noticeable upward trend.G-MANEC exhibit a highly invasive nature,frequently leading to lymphatic and distant metastases,which ultimately result in unfavorable prognosis.Consequently,this condition has garnered considerable interest among researchers.G-MANEC are characterized by the presence of adenocarcinoma and neuroendocrine carcinoma components,with each component comprising at least 30%of the tumor.In recent years,a growing body of knowledge regarding G-MANEC has led to a more comprehensive research approach towards this type of carcinoma.Nevertheless,there has been a notable deficiency to date in the examination of lymph node metastatic aspects of G-MANEC,which poses several pressing challenges that demand immediate resolutions.This review aims to systematically analyze previous case reports and studies on mixed neuroendocrine-non-neuroendocrine neoplasms(MiNEN)while incorporating research on gastric cancer.This study focuses on various aspects of G-MANEC,including the epidemiology,biological origin,diagnosis,patterns of lymph node metastasis,relationship with hematogenous metastasis,association between lymphatic and distant metastases,and treatment.The objective is to offer guidance for future research endeavors concerning G-MANEC.

关 键 词：胃混合性腺神经内分泌癌 淋巴结转移模式 血行和远处转移 

分 类 号：R735.2[医药卫生—肿瘤]