癫痫患者运动锻炼效果的Meta分析  

Effects of exercise on patients with epilepsy:a Meta-analysis

作　　者：宣烨菁 尹潇潇 牛姗 陈昊天 俞群[1] 封秀琴[1] 何乾峰 XUAN Yejing;YIN Xiaoxiao;NIU Shan;CHEN Haotian;YU Qun;FENG Xiuqin;HE Qianfeng(Nursing Department,The Affiliated Second Hospital of Zhejiang University School of Medicine,Hangzhou,310009,China)

机构地区：[1]浙江大学医学院附属第二医院护理部,杭州市310009 [2]空军军医大学第二附属医院护理部

出　　处：《中国护理管理》2024年第2期224-230,共7页Chinese Nursing Management

基　　金：浙江省医药卫生科技计划一般项目(2024KY1038)。

摘　　要：目的:通过Meta分析评价癫痫患者参与运动锻炼的干预效果,为临床实践提供循证依据。方法:系统检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库、中国知网、万方和维普数据库中关于癫痫患者参与运动锻炼的随机对照试验,检索时限为建库至2023年9月29日,采用RevMan 5.4软件进行Meta分析。结果:纳入9篇文献,共400例患者。Meta分析结果显示,运动锻炼可降低患者癫痫发作频率[MD=-2.35,95%CI(-3.16,-1.54),P<0.001],未增加不良事件发生[RR=2.54,95%CI(0.11,56.25),P=0.56],可提高患者每日活动量[MD=1.39,95%CI(0.48,2.29),P=0.003],改善患者抑郁症状[SMD=0.90,95%CI(0.22,1.58),P=0.01]、认知功能[SMD=0.69,95%CI(0.03,1.35),P=0.04]和生活质量[SMD=0.43,95%CI(0.22,0.64),P<0.001]。但在改善焦虑症状[SMD=-1.27,95%CI(-3.00,0.46),P=0.15]方面,差异没有统计学意义。结论:癫痫患者执行科学制定的运动锻炼方案具有安全性,且可以有效改善患者抑郁症状、认知功能和生活质量,但对于改善患者焦虑症状效果不显著。Objective:To conduct a Meta-analysis assessing the intervention effects of exercise participation in patients with epilepsy,aiming to provide evidence-based guidance for clinical practice.Methods:We searched randomized controlled trials on epilepsy patients having exercise from PubMed,Embase,Cochrane Library,Web of Science databases,CNKI,Wanfang database,VIP and CBM from their inception to September 29,2023.Meta-analysis was performed by RevMan 5.4.Results:A total of 9 studies involving 400 patients were finally included.The results showed that exercise reduced seizure frequency[MD=-2.35,95%CI(-3.16,-1.54),P<0.001],without an increased occurrence of adverse events[RR=2.54,95%CI(0.11,56.25),P=0.56].Furthermore,it could enhance the daily activity levels of patients[MD=1.39,95%CI(0.48,2.29),P=0.003],ameliorate depressive symptoms[SMD=0.90,95%CI(0.22,1.58),P=0.01],improve cognitive function[SMD=0.69,95%CI(0.03,1.35),P=0.04],and elevate the quality of life[SMD=0.43,95%CI(0.22,0.64),P<0.001].However,there was no statistically significant difference in improving anxiety symptoms[SMD=-1.27,95%CI(-3.00,0.46),P=0.15].Conclusion:The implementation of a scientifically developed exercise in patients with epilepsy was safe and effective in relieving depressive symptoms,improving cognitive function and life quality,but was not that obvious in reducing their anxiety symptoms.

关 键 词：癫痫 运动锻炼 随机对照试验 系统评价 META分析 

分 类 号：R47[医药卫生—护理学] R197[医药卫生—临床医学]