端粒逆转录酶基因多态性与贺州汉族长寿人群的关联研究  

Association study on telomerase reverse transcriptase gene polymorphisms and longevity in the Han Chinese population in Hezhou

作　　者：陈国宁 罗锦英 罗显森 莫蓓馨 陆莹 王晓刚 CHEN Guoning;LUO Jinying;LUO Xiansen;MO Beixin;LU Ying;WANG Xiaogang(Department of Blood Transfusion,Guidong People's Hospital of Guangxi Zhuang Autonomous Region,Guangxi Zhuang Autonomous Region,Wuzhou543001,China;Department of Laboratory,Guidong People's Hospital of Guangxi Zhuang Autonomous Region,Guangxi Zhuang Autonomous Region,Wuzhou543001,China;Legal Supervision Office,Guidong People's Hospital of Guangxi Zhuang Autonomous Region,Guangxi Zhuang Autonomous Region,Wuzhou543001,China)

机构地区：[1]广西壮族自治区桂东人民医院输血科,广西梧州543001 [2]广西壮族自治区桂东人民医院检验科,广西梧州543001 [3]广西壮族自治区桂东人民医院法制监督办,广西梧州543001

出　　处：《中国当代医药》2024年第6期25-28,共4页China Modern Medicine

基　　金：广西壮族自治区贺州市科学研究与技术开发计划项目(贺科技202101)。

摘　　要：目的探讨贺州汉族长寿人群与端粒酶逆转录酶(TERT)基因rs2075786和rs2736100位点的相关性。方法选取贺州汉族人群58例,作为研究对象,其中包括对照组30例,长寿组28例,应用测序法对TERT基因的rs2075786和rs2736100两位点进行基因分型检测,并研究TERT基因rs2075786和rs2736100位点构建的单倍体与长寿的关联性。结果TERT基因rs2075786和rs2736100两位点在两组基因及其等位基因分布频率差异无统计学意义(P>0.05);TERT基因rs2075786和rs2736100构建的单倍体与贺州汉族长寿人群无关联(P>0.05)。结论未发现TERT基因rs2075786和rs2736100位点与贺州汉族长寿人群存在相关性。Objective To explore the correlation between the telomerase reverse transcriptase(TERT)gene rs2075786 and rs2736100 polymorphisms and the Han Chinese population in longevity in Hezhou.Methods A total of 58 individuals from the Han Chinese population in Hezhou were selected as the research subjects,including 30 individuals in the control group and 28 individuals in the longevity group.The gene typing of the TERT gene rs2075786 and rs2736100 polymorphisms was determined using sequencing methods.The association between the haplotypes constructed by the TERT gene rs2075786 and rs2736100 polymorphisms and longevity was investigated.Results There were no statistically significant differences in the gene and allele frequencies distribution of the TERT gene rs2075786 and rs2736100 polymorphisms between the two groups(P>0.05).The haplotypes constructed by the TERT gene rs2075786 and rs2736100 polymorphisms were not associated with longevity in the Hezhou Han Chinese population(P>0.05).Conclusion No correlation was found between the TERT gene rs2075786 and rs2736100 polymorphisms and the Han Chinese population in longevity in Hezhou.

关 键 词：端粒逆转录酶 汉族 长寿 rs2075786 rs2736100 

分 类 号：R394[医药卫生—医学遗传学]