甲钴胺穴位注射防治奥沙利铂所致周围神经病变的疗效观察  

Observation on the therapeutic effect of Mecobalamin acupoint injection on the prevention and treatment of Oxaliplatin-induced peripheral neuropathy

作　　者：魏淑琴 张康梅 冷霞 钟睿[1] 黄凯[1] WEI Shuqin;ZHANG Kangmei;LENG Xia;ZHONG Rui;HUANG Kai(Department of Special Medical,Jiangxi Cancer Hospital,Jiangxi Province,Nanchang330029,China)

机构地区：[1]江西省肿瘤医院特需医疗科,江西南昌330029

出　　处：《中国当代医药》2024年第6期70-73,共4页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2021A045)。

摘　　要：目的探讨甲钴胺穴位注射防治奥沙利铂所致周围神经病变的疗效。方法选择2022年1月至12月于江西省肿瘤医院进行化疗的60例胃肠道肿瘤患者作为研究对象,采用随机数字表法分为治疗组与对照组,每组各30例。两组患者均予以含有奥沙利铂方案的化疗,此外,对照组肌肉注射甲钴胺,治疗组足三里穴注射甲钴胺。比较两组神经毒性发生情况、卡氏功能状态评分(KPS)以及生活质量。结果治疗组神经毒性发生程度轻于对照组,差异有统计学意义(P<0.05)。两组治疗前KPS评分、生活质量评分比较,差异无统计学意义(P>0.05);两组治疗后KPS评分、生活质量评分均低于本组治疗前,但治疗组治疗后KPS、社会功能、心理功能、躯体功能、物质生活各项评分均高于对照组,差异有统计学意义(P<0.05)。结论甲钴胺穴位注射能够较好地防治奥沙利铂所致周围神经病变,减轻神经毒性,为患者顺利完成化疗提供有利条件,减缓功能状态、生活质量下降速度,临床应用价值较高。Objective To investigate the effect of acupoint injection of Mecobalamin in the prevention and treatment of Oxaliplatin-induced peripheral neuropathy.Methods Sixty patients with gastrointestinal cancer were selected as the research subjects who underwent chemotherapy in the Jiangxi Cancer Hospital from January to December 2022.They were divided into treatment group and control group by random number table method,30 cases in each group.Both groups of patients were treated with chemotherapy containing Oxaliplatin regimen.In addition,patients in the control group were intramuscularly injected with Mecobalamin,and in the treatment group,they were injected with Mecobalamin at Zusanli(ST36)point.The incidence of neurotoxicity,Karnofsky performance status(KPS)score,and score of quality of life were compared between the two groups.Results The degree of neurotoxicity in the treatment group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no statistical difference in KPS score or quality of life score before treatment in both groups(P>0.05).The KPS score and quality of life score of the two groups after treatment were lower than those before treatment,the scores of KPS,social function,psychological function,physical function,and material life of the treatment group after treatment were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Mecobalamin acupoint injection can better prevent Oxaliplatin-induced peripheral neuropathy,reduce neurotoxicity,provide favorable regulation for patients to successfully complete chemotherapy,slow down the decline of functional status and quality of life,and has high clinical application value.

关 键 词：奥沙利铂 周围神经病变 甲钴胺穴位注射 生活质量 

分 类 号：R741[医药卫生—神经病学与精神病学]