非小细胞肺癌晚期患者白细胞介素-2、白细胞介素-6、肿瘤坏死因子-α和γ干扰素对生存情况的预测价值  

Predictive value of interleukin-2,interleukin-6,tumor necrosis factor-α,and interferon-γon survival in advanced non-small cell lung cancer patients

作　　者：张有华 张林锋 邱华平 郑奇[1] 罗景方 ZHANG Youhua;ZHANG Linfeng;QIU Huaping;ZHENG Qi;LUO Jingfang(Department of Oncology,the First People's Hospital of Fuzhou,Jiangxi Province,Fuzhou344000,China)

机构地区：[1]江西省抚州市第一人民医院肿瘤内科,江西抚州344000

出　　处：《中国当代医药》2024年第6期74-77,共4页China Modern Medicine

基　　金：江西省抚州市社会发展指导性科技计划项目(抚科计字〔2021〕21号)。

摘　　要：目的分析非小细胞肺癌(NSCLC)晚期患者血清中白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和γ干扰素(IFN-γ)变化与生存率的相关性。方法回顾性分析2021年10月至2022年9月在抚州市第一人民医院肿瘤内科确诊的60例NSCLC晚期患者临床资料,作为观察组,根据患者入院6个月后的预后情况将患者分为生存组(n=41)和死亡组(n=19),同期选择入院体检的66例健康人群为健康组。记录患者入院24 h内和治疗2个周期后的IL-2、IL-6、TNF-α、IFN-γ水平,比较治疗2个周期后的生存组和死亡组患者的IL-2、IL-6、TNF-α、IFN-γ水平,以患者的预后情况作为最终变量绘制NSCLC患者预后的ROC曲线图。结果健康组的IL-6水平低于观察组,IL-2、TNF-α和IFN-γ水平均高于观察组,差异均有统计学意义(P<0.05)。患者入院24 h内,死亡组IL-6水平高于生存组,差异有统计学意义(P<0.05)。两组患者入院治疗2个周期后,患者的IL-2水平较入院24 h内低,IL-6、TNF-α和IFN-γ水平较24 h内的指标水平高,差异均有统计学意义(P<0.05)。治疗2个周期后,生存组的IL-6较死亡组低,差异有统计学意义(P<0.05)。ROC结果显示,IL-6水平鉴别诊断NSCLC患者的预后的ROC曲线下面积为0.738,敏感度为89.47%,特异性为65.85%,此时IL-6水平的截断值为60.731 pg/ml(P<0.05)。结论NSCLC晚期患者的IL-6水平对其预后具有一定的预测效能,可以为临床NSCLC患者的治疗方案提供指导作用。Objective To analyze the relationship between serum levels of interleukin-2(IL-2),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and interferon-γ(IFN-γ)and survival in advanced patients with non-small cell lung cancer(NSCLC).Methods A retrospective analysis was performed on 60 patients with advanced NSCLC diagnosed in the Department of Oncology of the First People's Hospital of Fuzhou from October 2021 to September 2022,who were classified as observation group.According to the prognosis 6 months after admission,the patients were divided into survival group(n=41)and death group(n=19).In the same period,66 healthy people were selected as the healthy group.The levels of IL-2,IL-6,TNF-αand IFN-γwithin 24 h of admission and after 2 cycles of treatment were recorded,and the levels of IL-2,IL-6,TNF-αand IFN-γof patients in the survival group and the death group after 2 cycles of treatment were compared.The ROC curve of NSCLC patients'prognosis was drawn with the prognosis of patients as the final variable.Results The levels of IL-6 in healthy group were lower than those in observation group,and the levels of IL-2,TNF-αand IFN-γwere higher than those in observation group,with statistical significances(P<0.05).Within 24 h after admission,the level of IL-6 in the death group was higher than that in the survival group,and the difference was statistically significant(P<0.05).After 2 cycles of admission,the levels of IL-2 were lower than those within 24 h,and the levels of IL-6,TNF-αand IFN-γwere higher than those within 24 h,with statistical significance(P<0.05).After 2 cycles of treatment,IL-6 in survival group was lower than that in death group,and the difference was statistically significant(P<0.05).ROC results showed that the area under ROC curve,sensitivity,specificity and cut-off value of IL-6 level in the differential diagnosis of NSCLC patients were 0.738,89.47%,65.85%,60.731 pg/ml(P<0.05).Conclusion IL-6 level can predict the prognosis of advanced NSCLC patients to a certain extent,and can provide gui

关 键 词：非小细胞肺癌 白细胞介素-2 白细胞介素-6 Γ干扰素 生存率 

分 类 号：R734[医药卫生—肿瘤]