合并人类乳头瘤病毒16型、18型感染的宫颈小细胞癌1例及文献复习  

A case of cervical small cell carcinoma complicated with infection of human papilloma virus 16 and 18 and literature review

作　　者：么童童 刘志强[1] 刘伟龙 于文静 YAO Tongtong;LIU Zhiqiang;LIU Weilong;YU Wenjing(Department of Gynecology,Binzhou Medical University Hospital,Shandong Province,Binzhou256603,China)

机构地区：[1]滨州医学院附属医院妇科,山东滨州256603

出　　处：《中国当代医药》2024年第6期150-153,共4页China Modern Medicine

摘　　要：持续高危型人乳头瘤病毒(HPV)感染是导致宫颈恶性肿瘤发生发展的主要病因,因此,人们通常认为宫颈小细胞癌的发病与HPV感染的关系密切。目前在宫颈癌症患者中,超过90%可以检测到高危型HPV16型和18型感染。宫颈小细胞神经内分泌癌(SCNECC)是一种发病率低、侵袭性强、预后较差的原发性宫颈恶性肿瘤,最近的研究表明,SCNECC是HPV驱动的,但尚未建立像HPV感染与宫颈鳞状细胞癌、腺癌一样的因果关系。主要原因是其临床样本量少,相关研究证据不足,其与HPV感染之间的相关性难以定论。本文报告了一例罕见的合并HPV16型、18型感染的宫颈小细胞癌,详细描述了其临床诊断和治疗过程,分析宫颈小细胞癌的免疫学组化特点,总结经验,并结合最新文献进一步探讨宫颈小细胞癌与HPV感染的相关性,以期与临床医师一同进行探讨与学习,为宫颈小细胞癌的诊疗提供新思路。Persistent high-risk human papillomavirus(HPV)infection is the main cause of cervical malignant tumors.Therefore,it was generally believed that the incidence of cervical small cell carcinoma was also closely related to HPV infection.Currently,over 90%of cervical cancer patients can detect high-risk HPV16 and 18 infections.Small cell neuroendocrine carcinoma of the cervix(SCNECC)is a primary malignant tumor with low incidence rate,strong invasion and poor prognosis.Recent studies show that SCNECC was driven by HPV,but no causal relationship had been established between HPV infection and cervical squamous cell carcinoma and adenocarcinoma.The main reason was that the clinical sample size was small,the relevant research evidence was insufficient,and the correlation between HPV infection was difficult to be defined.In this article,we reported a rare case of cervical small cell carcinoma with HPV 16 and 18 infections,described its clinical diagnosis and treatment process in detail,analyzed the immunohistochemistry characteristics of cervical small cell carcinoma,summarized the experience,and further explored the correlation between cervical small cell carcinoma and HPV infection by referring to the latest literature,in order to discuss and learn with clinicians,and provide new ideas for the diagnosis and treatment of cervical small cell carcinoma.

关 键 词：宫颈恶性肿瘤 宫颈小细胞癌 小细胞癌 人类乳头瘤病毒感染 

分 类 号：R737.3[医药卫生—肿瘤]