磁共振弥散加权成像联合血清CYFRA211在直肠癌术前分期诊断中的应用价值  

Application value of magnetic resonance imaging-diffusion weighted imaging combined with serum CYFRA211 in preoperative staging diagnosis of rectal cancer

作　　者：李晓成 孟宪平[1] 费锋[1] LI Xiaocheng;MENG Xianping;FEI Feng(Department of Radiology,Jiangyin Hospital Affiliated to Southeast University School of Medicine,Jiangsu Province,Wuxi 214400,China)

机构地区：[1]东南大学医学院附属江阴医院放射科,江苏无锡214400

出　　处：《中国医药导报》2024年第4期21-24,69,共5页China Medical Herald

基　　金：江苏省重点研发计划项目(BE2022728)。

摘　　要：目的 分析磁共振弥散加权成像(MRI-DWI)联合血清CYFRA211在直肠癌术前分期诊断中的应用价值。方法 回顾性分析2020年1月至2023年4月东南大学医学院附属江阴医院收治的124例直肠癌患者的临床资料。以病理结果为金标准,分析MRI-DWI联合血清CYFRA211对直肠癌术前T、N分期的诊断价值。结果 病理结果显示,124例直肠癌患者中,T_(1)期16例、T_(2)期14例、T_(3)期46例、T_(4)期48例;N_(0)期54例、N_(1)期40例、N_(2)期30例。T_(4)期患者血清CYFRA211高于T_(1)、T_(2)、T_(3)期,T_(3)期患者血清CYFRA211高于T_(1)、T_(2)期,T_(2)期患者血清CYFRA211高于T_(1)期(P<0.05)。N_(2)期患者血清CYFRA211高于N_(0)、N_(1)期,N_(1)期患者血清CYFRA211高于N_(0)期(P<0.05)。血清CYFRA211诊断直肠癌术前T_(1)、T_(2)、T_(3)、T_(4)、N_(0)、N_(1)、N_(2)期曲线下面积分别为0.756、0.744、0.805、0.897、0.791、0.813、0.821。MRI-DWI对术前T_(1)、T_(2)、T_(3)、T_(4)期的诊断一致性一般(Kappa=0.452、0.587、0.672、0.720,P<0.01);MRI-DWI联合血清CYFRA211对术前T_(1)、T_(2)、T_(3)、T_(4)期的诊断一致性较好(Kappa=0.768、0.785、0.827、0.839,P<0.01)。MRI-DWI对术前N_(0)、N_(1)、N_(2)期的诊断一致性一般(Kappa=0.473、0.598、0.682,P<0.01),MRI-DWI联合血清CYFRA211对术前N_(0)、N_(1)、N_(2)期的诊断一致性较好(Kappa=0.795、0.821、0.834,P<0.01)。结论 MRI-DWI联合血清CYFRA211在直肠癌术前T、N分期的诊断价值更高。Objective To evaluate the application value of magnetic resonance imaging-diffusion weighted imaging(MRI-DWI) combined with serum CYFRA211 in preoperative staging diagnosis of rectal cancer.Methods The clinical data of 124 patients with rectal cancer admitted to Jiangyin Hospital Affiliated to Southeast University School of Medicine from January 2020 to April 2023 were retrospectively analyzed.Using pathological results as the gold standard,the diagnostic value of MRI-DWI combined with serum CYFRA211 in preoperative T and N stages of rectal cancer was analyzed.Results The pathological results showed that there were 16 cases of stage T_1,14 cases of stage T_2,46 cases of stage T_3,and 48 cases of stage T_4.There were 54 cases of stage N_0,40 cases of stage N_1,and 30 cases of stage N_2.Serum CYFRA211 in patients with stage T_(4was) higher than that with stage T_1,T_2,and T_3;serum CYFRA211 in patients with stage T_(3was) higher than that with stage T_(1and) T_2,and serum CYFRA211 in patients with stage T_(2was) higher than that with stage T_1(P<0.05).Serum CYFRA211 in patients with stage N_(2was) higher than that with stage N_(0and) N_1,and serum CYFRA211 in patients with stage N_(1was) higher than that in stage N_0(P<0.05).The area under the curve of preoperative diagnosis of stage T_1,T_2,T_3,T_4,N_0,N_1,and N_(2of) rectal cancer by serum CYFRA211 was 0.756,0.744,0.805,0.897,0.791,0.813,and 0.821,respectively.MRI-DWI was generally consistent in the preoperative diagnosis of stage T_1,T_2,T_3,and T_4(Kappa=0.452,0.587,0.672,0.720,P<0.01);MRI-DWI combined with serum CYFRA211 showed good consistency in the preoperative diagnosis of stage T_1,T_2,T_3,and T_4(Kappa=0.768,0.785,0.827,0.839,P<0.01).MRI-DWI was generally consistent in the preoperative diagnosis of stage N_0,N_(1) and N_2(Kappa=0.473,0.598,0.682,P <0.01).MRI-DWI combined with serum CYFRA211 showed good consistency in preoperative diagnos is of stage N_0,N_1,and N_2(Kappa=0.795,0.821,0.834,P<0.01).Conclusion MRI-DWI combined with serum CYFRA211 has higher

关 键 词：磁共振弥散加权成像 CYFRA211 直肠癌 术前分期 

分 类 号：R735.3[医药卫生—肿瘤]