丝状噬菌体作为胶质瘤治疗载体的应用进展  

Application progress of filamentous bacteriophages as glioma therapeutic vectors

作　　者：宋钰辉 王忠 张晓军 杨蔚然 张之龙 SONG Yuhui;WANG Zhong;ZHANG Xiaojun;YANG Weiran;ZHANG Zhilong(Graduate School,Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Hohhot010000,China;Department of Neurosurgery,Inner Mongolia Autonomous Region People’s Hospital,Inner Mongolia Autonomous Region,Hohhot010000,China)

机构地区：[1]内蒙古医科大学研究生学院,内蒙古呼和浩特010000 [2]内蒙古自治区人民医院神经外科,内蒙古呼和浩特010000

出　　处：《中国医药导报》2024年第4期49-53,共5页China Medical Herald

基　　金：内蒙古自治区卫生健康委员会基金资助项目(202201059)。

摘　　要：胶质瘤的术后治疗包括放化疗及靶向治疗,因此治疗载体的选择尤为重要。丝状噬菌体凭借其血脑屏障穿透力强,与肿瘤细胞特异性结合、携带多种外源性DNA使其成为胶质瘤治疗载体具有优良优势。本文对近年来丝状噬菌体的研究作一综述,阐述其作为治疗载体的理化性质,指出目标噬菌体的分离方法及在中枢神经系统的应用,并与其他治疗载体相对比,为胶质瘤治疗提供新思路并对个体化治疗进行展望。Postoperative treatment of gliomas includes chemoradiotherapy and targeted therapy,so the choice of treatment vehicle is particularly important.Filamentous bacteriophages have excellent advantages due to their strong penetration of the blood-brain barrier,specific binding to tumor cells,and carrying a variety of exogenous DNA,making them glioma treatment vectors.This article reviews the research on filamentous bacteriophages in recent years,elaborates their physicochemical properties as therapeutic carriers,points out the isolation method of target phages and their application in the central nervous system,and compares them with other therapeutic vectors to provide new ideas for glioma treatment and prospect individualized treatment.

关 键 词：丝状噬菌体 胶质瘤 载体 靶向治疗 

分 类 号：R730.51[医药卫生—肿瘤]