89例子宫内膜癌患者的临床特征及其预后影响因素分析  

Analysis of clinical features and prognostic factors of 89 patients with endometrial cancer

作　　者：姚培培 黄晓娟 王晓敏 YAO Peipei;HUANG Xiaojuan;WANG Xiaomin(Department of Obstetrics and Gynecology,Xuchang Hospital,Xuchang 461000,Henan,China)

机构地区：[1]许昌医院妇产科,河南许昌461000

出　　处：《中国校医》2023年第11期866-868,880,共4页Chinese Journal of School Doctor

摘　　要：目的探讨子宫内膜癌的临床特征,并分析预后的影响因素。方法对2010年1月—2017年6月在某院妇产科就诊的89例子宫内膜癌患者进行回顾性调查。预后因素采用单因素/多因素分析法,生存率评估采用Kaplan-Meier方法。采用COX回归模型对影响预后的独立因素进行评估。结果89例患者生存期为2~135.6个月,平均生存期为(57.38±33.51)个月。术后1、3、5年生存率分别为96.63%、84.27%、75.28%。COX回归分析显示,腹腔镜术(HR=1.745,95%CI:1.190~2.558,P=0.004)、未采取术后辅助治疗(HR=1.960,95%CI:1.298~2.958,P=0.001)、病理类型为透明细胞癌(HR=1.907,95%CI:1.542~2.360,P<0.001)、病理类型为浆液性癌或癌肉瘤(HR=2.321,95%CI:1.897~2.840,P<0.001)、FIG OⅢ期(HR=1.779,95%CI:1.393~2.271,P<0.001)、FIGOⅣ期(HR=2.828,95%CI:2.828,P<0.001)是子宫内膜癌预后的独立影响因素。结论手术方式、术后辅助治疗、病理类型、FIGO分期是影响子宫内膜癌患者术后预后的独立因素。Objective To investigate the clinical features of endometrial cancer and analyze the prognostic factors.Methods A retrospective survey was conducted among 89 patients with endometrial cancer who visited the Department of Obstetrics and Gynecology of a hospital from January 2010 to June 2017.Prognostic factors were analyzed by using univari⁃ate/multivariate analyses,and the survival rate was assessed by using the Kaplan⁃Meier approach.The COX regression model was used to evaluate the independent factors affecting prognosis.Results The survival time of 89 patients was 2-135.6 months,and the average survival time was(57.38±33.51)months.The survival rates of 1,3,and 5 years after surgery were 96.63%,84.27%,and 75.28%,respectively.COX regression analysis showed that laparoscopy(HR=1.745,95%CI:1.190-2.558,P=0.004),no postoperative adjuvant therapy(HR=1.960,95%CI:1.298-2.958,P=0.001),the pathological type being clear cell carcinoma(HR=1.907,95%CI:1.542-2.360,P<0.001),the pathological type being serous carcinoma or carcinosar⁃coma(HR=2.321,95%CI:1.897-2.840,P<0.001),FIGO stageⅢ(HR=1.779,95%CI:1.393-2.271,P<0.001),and FIGO stageⅣ(HR=2.828,95%CI:2.828,P<0.001)were independent influencing factors on the prognosis of endometrial cancer.Conclusion Surgical method,postoperative adjuvant therapy,pathological type,and FIGO stage are independent factors affecting the postoperative prognosis of patients with endometrial cancer.

关 键 词：子宫内膜癌 临床特征 预后 生存期分析 

分 类 号：R737.33[医药卫生—肿瘤]