柴胡加龙骨牡蛎汤联合盐酸帕罗西汀片治疗抑郁症临床研究  

Clinical Study on Chaihu and Longgu Muli Decoction Combined with Paroxetine Hydrochloride Tablets for Depression

作　　者：李阳 王莹 闵哥庆 吴云 LI Yang;WANG Ying;MIN Geqing;WU Yun(The Ninth Ward,The Second People's Hospital of Lishui,Lishui Zhejiang 323000,China)

机构地区：[1]丽水市第二人民医院九病区,浙江丽水323000

出　　处：《新中医》2024年第2期38-41,共4页New Chinese Medicine

摘　　要：目的:观察柴胡加龙骨牡蛎汤联合盐酸帕罗西汀片治疗抑郁症的临床疗效。方法:将84例抑郁症患者纳入研究,按随机数字表法分为治疗组与对照组各42例。对照组给予盐酸帕罗西汀片治疗,治疗组给予柴胡加龙骨牡蛎汤联合盐酸帕罗西汀片治疗。治疗8周后评估2组临床疗效、中医证候积分、汉密顿抑郁量表(HAMD)及匹茨堡睡眠质量指数量表(PSQI)评分、血清脑源性神经营养因子(BDNF)、5-羟色胺(5-HT)水平。结果:治疗组总有效率为95.24%,对照组为80.95%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分均较治疗前降低(P<0.05),且治疗组中医证候积分低于对照组(P<0.05)。治疗后,2组HAMD、PSQI评分均较治疗前降低(P<0.05),且治疗组HAMD、PSQI评分均低于对照组(P<0.05)。治疗后,2组BDNF、5-HT水平均较治疗前升高(P<0.05),且治疗组BDNF、5-HT水平均高于对照组(P<0.05)。结论:柴胡加龙骨牡蛎汤联合盐酸帕罗西汀片治疗抑郁症疗效确切,对缓解临床症状、抑郁程度及提高睡眠质量有显著效果,并能有效调节神经因子及神经递质水平。Objective:To observe the clinical effect of Chaihu and Longgu Muli Decoction combined with Paroxetine Hydrochloride Tablets on depression.Methods:A total of 84 cases of patients with depression were included in the study,and were divided into the treatment group and the control group according to the random number table method,with 42 cases in each group.The control group was treated with Paroxetine Hydrochloride Tablets,and the treatment group was treated with Chaihu and Longgu Muli Decoction combined with Paroxetine Hydrochloride Tablets.After 8 weeks of treatment,the clinical effects,traditional Chinese medicine(TCM) syndrome scores,Hamilton Depression Scale(HAMD)scores,Pittsburgh Sleep Quality Index(PSQI) scores,and the levels of brain-derived neurotrophic factors(BDNF) and 5-hydroxytryptin(5-HT) in serum in the two groups were evaluated.Results:The total effective rate was 95.24% in the treatment group and 80.95% in the control group,the difference being significant(P<0.05).After treatment,TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome score in the treatment group was lower than that in the control group(P<0.05).After treatment,the scores of HAMD and PSQI in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of HAMD and PSQI in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of BDNF and 5-HT in the two groups were increased when compared with those before treatment(P<0.05),and the levels of BDNF and 5-HT in the treatment group were higher than those in the control group(P<0.05).Conclusion:Chaihu and Longgu Muli Decoction combined with Paroxetine Hydrochloride Tablets has a definite curative effect on depression,which can significantly relieve clinical symptoms,improve depression degree and sleep quality,and can effectively regulate the levels of neurological factors and neurotransmitters.

关 键 词：抑郁症 柴胡加龙骨牡蛎汤 盐酸帕罗西汀片 脑源性神经营养因子 5-羟色胺 

分 类 号：R749.4[医药卫生—神经病学与精神病学]