血府逐瘀汤联合布洛芬、氟桂利嗪治疗瘀阻脑络型血管性头痛临床疗效及对脑血流动力学的影响  

Clinical Effect of Xuefu Zhuyu Decoction Combined with Ibuprofen and Flunarizine for Vascular Headache of Stasis Obstructing the Brain Collateral Type and Its Effect on Cerebral Hemodynamics

作　　者：佘秋熳 陈玉峰 吴玉[3] SHE Qiuman;CHEN Yufeng;WU Yu(General Department,Lishui People's Hospital,Lishui Zhejiang 323000,China;Department of Critical Care Medicine,Lishui People's Hospital,Lishui Zhejiang 323000,China;Department of Neurology,Lishui People's Hospital,Lishui Zhejiang 323000,China)

机构地区：[1]丽水市人民医院全科,浙江丽水323000 [2]丽水市人民医院重症医学科,浙江丽水323000 [3]丽水市人民医院神经内科,浙江丽水323000

出　　处：《新中医》2024年第2期156-159,共4页New Chinese Medicine

摘　　要：目的:观察血府逐瘀汤联合布洛芬、氟桂利嗪治疗瘀阻脑络型血管性头痛的临床疗效及对脑血流动力学的影响。方法:选取血管性头痛患者96例作为研究对象,按照随机数字表法分为治疗组和对照组各48例。对照组给予布洛芬联合氟桂利嗪治疗,治疗组在对照组基础上加用血府逐瘀汤治疗。比较2组临床疗效及不良反应发生率,治疗前后头痛视觉模拟评分法(VAS)评分、发作频率及持续时间、脑血流动力学指标[收缩期血流速度(Vs)、平均血流速度(Vm)、血管搏动指数(PI)、血管阻力指数(RI)]水平。结果:治疗组总有效率为93.75%,对照组为75.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组头痛VAS评分、发作频率及持续时间均较治疗前降低(P<0.05),且治疗组上述3项指标均低于对照组(P<0.05)。治疗后,2组Vs、Vm水平均较治疗前升高(P<0.05),PI、RI水平均较治疗前降低(P<0.05);且治疗组Vs、Vm水平高于对照组(P<0.05),PI、RI水平低于对照组(P<0.05)。治疗组不良反应发生率为8.33%,对照组为6.25%,2组比较,差异无统计学意义(P>0.05)。结论:血府逐瘀汤联合布洛芬、氟桂利嗪治疗瘀阻脑络型血管性头痛疗效显著,可有效缓解头痛发作,改善脑血流动力学状态,且无明显增加不良反应。Objective:To observe the clinical effect of Xuefu Zhuyu Decoction combined with Ibuprofen and Flunarizine for vascular headache of stasis obstructing the brain collateral type and its effect on cerebral hemodynamics.Methods:A total of 96 patients with vascular headache were selected as the research subjects and divided into the treatment group and the control group according to the random number table method,with 48 cases in each group.The control group was treated with Ibuprofen combined with Flunarizine,and the treatment group was additionally treated with Xuefu Zhuyu Decoction based on the treatment of the control group.The clinical effects and incidence of adverse reactions were compared between the two groups.The Visual Analogue Scale(VAS) scores of headache,the frequency and duration of attacks,and the levels of cerebral hemodynamic indicators such as systolic blood flow velocity(Vs),mean blood flow velocity(Vm),pulsatile index(PI),and vascular resistance index(RI) were compared before and after treatment.Results:The total effective rate was 93.75% in the treatment group,and75.00% in the control group,the difference being significant(P<0.05).After treatment,the VAS scores of headache,and frequency and duration of attacks in the two groups were decreased when compared with those before treatment(P<0.05),and the above three indexes in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of Vs and Vm in the two groups were increased when compared with those before treatment(P<0.05),and the levels of PI and RI were decreased when compared with those before treatment(P<0.05);the levels of Vs and Vm in the treatment group were higher than those in the control group(P<0.05),and the levels of PI and RI were lower than those in the control group(P<0.05).The incidence of adverse reactions was 8.33% in the treatment group and 6.25% in the control group,there being no significant difference between the two groups(P>0.05).Conclusion:The combination of Xuefu Zhuyu Decoction co

关 键 词：血管性头痛 瘀阻脑络型 血府逐瘀汤 布洛芬 氟桂利嗪 血流动力学 

分 类 号：R747.2[医药卫生—神经病学与精神病学]