立体定向微创手术对脑胶质瘤患者神经功能的影响  

Effect of stereotactic minimally invasive surgery on neurological function in patients with brain glioma

作　　者：杨永飞 王彪 尹凯[1] 王天恩[1] 左玉超[1] YANG Yongfei;WANG Biao;YIN Kai;WANG Tianen;ZUO Yuchao(Department of Neurosurgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州大学第一附属医院神经外科,郑州450000

出　　处：《癌症进展》2024年第1期36-39,共4页Oncology Progress

基　　金：河南省医学科技攻关计划省部共建重点项目(SBGJ202102128)。

摘　　要：目的探讨立体定向微创手术对脑胶质瘤患者神经功能的影响。方法将100例脑胶质瘤患者根据治疗方法的不同分为传统组和微创组,每组50例,传统组行传统开颅肿瘤切除术,微创组行立体定向微创手术。比较两组患者的手术指标、临床疗效、神经肽水平、美国国立卫生研究院卒中量表(NIHSS)评分、格拉斯哥昏迷量表(GCS)评分、日常生活能力(ADL)评分以及术后并发症发生情况。结果微创组患者手术时间、住院时间均短于传统组,差异均有统计学意义(P﹤0.05)。微创组患者的总有效率为80.00%,高于传统组患者的62.00%,差异有统计学意义(P﹤0.05)。术后1年,两组患者的精氨酸升压素、β-内啡肽水平均低于本组术前,但微创组患者的精氨酸升压素、β-内啡肽水平均高于传统组,差异均有统计学意义(P﹤0.05)。术后3个月,两组患者的NIHSS评分均低于本组术前,且微创组患者的NIHSS评分低于传统组,两组患者的GCS、ADL评分均高于本组术前,且微创组患者的GCS、ADL评分均高于传统组,差异均有统计学意义(P﹤0.05)。微创组患者的并发症总发生率为8.00%,低于传统组患者的24.00%,差异有统计学意义(P﹤0.05)。结论立体定向微创手术应用于脑胶质瘤患者的治疗中,可缩短手术时间与住院时间,提高临床疗效,减轻对患者神经系统的损伤,改善神经缺损状况,从而有助于提高患者的日常生活能力,降低并发症发生率。Objective To investigate the effect of stereotactic minimally invasive surgery on neurological function in patients with brain glioma.Method A total of 100 patients with brain glioma were divided into traditional group and minimally invasive group according to different treatment methods,with 50 cases in each group.The traditional group underwent traditional craniotomy,and the minimally invasive group underwent stereotactic minimally invasive surgery.The surgical indicators,clinical efficacy,neuropeptide levels,National Institutes of Health stroke scale(NIHSS)scores,Glasgow coma scale(GCS)scores,activity of daily living(ADL)scores,and postoperative complications were compared between the two groups.Result The surgical time and hospitalization time in the minimally invasive group were shorter than those in the traditional group,and the differences were statistically significant(P<0.05).The total effective rate in minimally invasive group was 80.00%,which was higher than 62.00%in traditional group,and the difference was statistically significant(P<0.05).One year after surgery,the levels of arginine vasopressin andβ-endorphin in the two groups were lower than those before surgery,the levels of arginine vasopressin andβ-endorphin in the minimally invasive group were higher than those of the traditional group,and the differences were statistically significant(P<0.05).Three months after surgery,the NIHSS scores of the two groups were lower than those before surgery,and the NIHSS score of the minimally invasive group was lower than that of the traditional group,the GCS and ADL scores of the two groups were higher than those before surgery,and the GCS and ADL scores of the minimally invasive group were higher than those of the traditional group,and the differences were statistically significant(P<0.05).The total incidence of complications in the minimally invasive group was 8.00%,which was lower than 24.00%of the traditional group,and the difference was statistically significant(P<0.05).Conclusion The application of st

关 键 词：立体定向微创手术 脑胶质瘤 神经功能 

分 类 号：R739.41[医药卫生—肿瘤]