Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health  

作　　者：ZHAO Wen-xiao WANG Tong ZHANG Ya-nan CHEN Qian WANG Yuan XING Yan-qing ZHENG Jun DUAN Chen-chen CHEN Lijun ZHAO Hai-jun WANG Shijun 

机构地区：[1]School of Nursing,Shandong University of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Ji'nan(250355),China [2]Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula,Shandong University of Traditional Chinese Medicine,Ji'nan(250355),China [3]College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan(250355),China

出　　处：《Chinese Journal of Integrative Medicine》2024年第2期171-180,共10页中国结合医学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81903947);the Key Research and Development Project of Shandong Province,China(No.2019GSF108209);Key Basic Research of the Natural Science Foundation of Shandong Province,China(No.ZR2019ZD23);Shandong University Youth Innovative Talent Introduction Project(LJRZ 2019,No.9-201)。

摘　　要：The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver disease.Polysaccharides extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and anti-oxidation.The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment.In addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota.This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关 键 词：Chinese medicine POLYSACCHARIDES gut microbiota short-chain fatty acids LIPOPOLYSACCHARIDES gut-organaxis synergistic actions 

分 类 号：R285[医药卫生—中药学]