免疫球蛋白G4相关性唾液腺炎临床特点及诊疗进展  

Diagnosis and treatment progress and clinical characteristics of immunoglobulin G4-related sialadenitis

作　　者：张宇 贾志宇[2] 唐慧芳 张志勇[1] 李文静[1] 田松波[1] Zhang Yu;Jia Zhiyu;Tang Huifang;Zhang Zhiyong;Li Wenjing;Tian Songbo(Dept.of Oral Medicine,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Dept.of Oral and Maxillofacial Surgery,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院口腔内科,石家庄050000 [2]河北医科大学第二医院口腔颌面外科,石家庄050000

出　　处：《国际口腔医学杂志》2024年第2期193-200,共8页International Journal of Stomatology

基　　金：河北省自然科学基金(H2019206129)。

摘　　要：免疫球蛋白G4相关性唾液腺炎(IgG4-RS)是一种与IgG4密切相关的慢性自身免疫性疾病,其发病率低,病因和发病机制尚不明确,以唾液腺尤其是颌下腺无痛性持续性肿大为主要临床表现,多数患者血清IgG4升高,淋巴浆细胞浸润,后期全身多器官可继发病变,组织病理学是该病最可靠的诊断方法。临床上倾向于传统糖皮质激素作为首选用药,现阶段可尝试应用生物制剂进行靶向治疗。本文根据国内外文献,对IgG4-RS的病因、临床表现、诊断与鉴别诊断、治疗和预后的研究进展作一综述,以期为该病的临床诊疗和研究提供帮助。Immunoglobulin G4-related sialadenitis(IgG4-RS)is a chronic autoimmune disease closely associated with IgG4.This disease is an uncommon disorder in the clinical setting,and its etiology is unknown.The major clinical features of IgG4-RS is a painless,persistent enlargement of the salivary gland,especially the submandibular gland.Peripheral blood examination show that IgG4 levels are elevated in the serum of most patients,and their lymphoplasmic cells are infiltrated.In the advanced stage of the disease,tissue lesions can present in various organs of the body.Histopathology is the most reliable diagnostic method.Glucocorticoids are recommended as the primary clinical treatment.Biologics can also be used as targeted therapy at this stage.Based on domestic and international literature,we review herein the etiology,clinical manifestations,diagnosis and differential diagnosis,and treatment and prognosis of IgG4-RS to aid the diagnosis,treatment,and subsequent research of the disease.

关 键 词：免疫球蛋白G4 唾液腺炎 免疫反应 诊断 治疗 

分 类 号：R781.72[医药卫生—口腔医学]