精神分裂症伴抑郁症患者血清iNOS、TBARS水平及其与疾病严重程度的相关性研究  

Serum levels of iNOS and TBARS in patients with schizophrenia accompanied by depression and their correlations with the disease severity

作　　者：王津鑫 陈衍华 王娟[1] WANG Jinxin;CHEN Yanhua;WANG Juan(Wuhan Mental Health Center,Wuhan 430000,China)

机构地区：[1]武汉市精神卫生中心,湖北武汉430000 [2]武汉市江岸区疾病预防控制中心

出　　处：《精神医学杂志》2023年第3期246-250,共5页Journal of Psychiatry

基　　金：武汉市医学科研项目(编号:WX21Z43)。

摘　　要：目的探究精神分裂症伴抑郁症患者血清诱导型一氧化氮合酶(iNOS)、硫代巴比妥酸反应物(TBARS)水平及其与疾病严重程度的相关性。方法选取123例精神分裂症患者,根据患者是否伴有抑郁症分为伴抑郁症组60例和未伴抑郁症组63例,另选同期无精神疾病者60名为对照组;酶联免疫法检测血清iNOS、TBARS水平,收集精神分裂症患者基本资料和阳性与阴性症状量表(PANSS)、重复性成套神经心理状态测验(RBANS)评分;采用Pearson法分析血清iNOS与TBARS水平相关性,Spearman法分析血清iNOS、TBARS水平与PANSS、RBANS评分相关性;Logistic回归分析影响精神分裂症患者出现抑郁症的因素;ROC曲线评估血清iNOS、TBARS水平对精神分裂症患者出现抑郁症的预测价值。结果三组血清iNOS、TBARS水平比较差异均有统计学意义(P<0.001)。进一步两两比较结果显示,伴抑郁症组和未伴抑郁症组血清iNOS、TBARS水平均高于对照组(P<0.05),伴抑郁症组血清iNOS、TBARS水平均高于未伴抑郁症组(P<0.05)。伴抑郁症组和未伴抑郁症组婚姻状况、社会经济地位和社会孤立方面比较,差异均有统计学意义(P<0.05);伴抑郁症组PANSS评分高于未伴抑郁症组,RBANS评分低于未伴抑郁症组(P<0.001)。相关分析结果显示,精神分裂症患者血清iNOS与TBARS水平呈正相关(P<0.05),血清iNOS、TBARS水平与PANSS评分均呈正相关,与RBANS评分均呈负相关(P<0.001)。Logistic回归分析结果表明,iNOS、TBARS、社会孤立是精神分裂症患者伴抑郁症的影响因素(P<0.05)。ROC曲线分析结果表明,血清iNOS、TBARS水平联合评估精神分裂症患者出现抑郁症的AUC大于iNOS、TBARS单独检测(P<0.001)。结论精神分裂症患者血清iNOS、TBARS水平均升高,与患者出现抑郁症关系密切,二者联合对预测精神分裂症患者出现抑郁症具有重要价值。Objective To explore the serum levels of inducible nitric oxide synthase(iNOS)and thiobarbituric acid reactants(TBARS)in patients with schizophrenia accompanied by depression,and their correlations with the disease severity.Methods A total of 123 patients with schizophrenia were selected,and divided into depression-accompany group(60 cases)and non-depression-accompany group(63 cases)according to whether the patient was accompanied by depression.Another 60 healthy controls without mental disorders during the same period were collected as control group.Enzyme-linked immunosorbent assay was applied to detect the serum levels of iNOS and TBARS.All the patients were assessed with basic information questionnaire,Positive and Negative Syndrome Scale(PANSS),and Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Pearson method was applied to analyze the correlation between serum levels of iNOS and TBARS;Spearman method was applied to analyze the correlations among serum levels of iNOS,TBARS,and scores of PANSS and RBANS.Logistic regression was applied to analyze the factors that affected the occurrence of depression in patients with schizophrenia;ROC curve was applied to evaluate the predictive values of serum levels of iNOS and TBARS for depression in patients with schizophrenia.Results There existed significant differences in serum levels of iNOS and TBARS among three groups(P<0.001).The serum levels of iNOS and TBARS in depression-accompany group and non-depression-accompany group were higher than those in control group(P<0.05),and above indicators in depression-accompany group were higher than those in non-depression-accompany group(P<0.05).Depression-accompany group and non-depression-accompany group showed different marital statuses,socioeconomic statuses,and social isolations(P<0.05).Depression-accompany group showed higher PANSS score and lower RBANS score than non-depression-accompany group(P<0.001).Pearson analysis showed that there was a positive correlation between serum iNOS level and T

关 键 词：精神分裂症 抑郁症 诱导型一氧化氮合酶 硫代巴比妥酸反应物 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]