基于铁死亡探讨防治溃疡性结肠炎的机制  

Mechanism of prevention and treatment of ulcerative colitis from the perspective of iron death

作　　者：张尔馨 郝微微 王珠环 时艺榕 Er-Xin Zhang;Wei-Wei Hao;Zhu-Huan Wang;Yi-Rong Shi(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海市201203

出　　处：《世界华人消化杂志》2024年第2期109-115,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金,No.81874450和81403362;上海市中医优势病种培育建设项目,No.ZY(2018-20200-ZYBZ-03);上海市中医诊疗模式创新试点建设项目,No.ZY(2018-20200-FWTX-6028).

摘　　要：溃疡性结肠炎(ulcerative colitis,UC)是一种慢性炎症性肠道疾病,其病因和发病机制尚未完全明确.随着社会的发展和压力的增加,UC患者数量持续增加,尤其是在亚洲,且与健康个体相比,UC患者患结直肠癌的风险大大增加.虽然目前其具体发病机制尚不清楚,但研究表明与免疫系统、环境、肠道微生态平衡、遗传等多种因素密切相关.UC患者体内与UC模型会发生铁死亡损伤,且在运用铁死亡抑制剂后可有效缓解症状.铁死亡是一种新形式的调节性细胞死亡,是由铁过度积累和脂质过氧化引起的,其特征是铁沉积、脂质过氧化异常和氨基酸代谢异常.本文就铁死亡的三大特征探讨基于铁死亡防治UC的机制及治疗策略作一综述.Ulcerative colitis(UC)is a chronic inflammatory bowel disease,the etiology and pathogenesis of which have not been fully clarified.As society develops and stress increases,the number of patients with UC continues to increase,especially in Asia.The risk of colorectal cancer is greatly increased in patients with UC compared to healthy individuals.Although the exact pathogenesis of the disease is currently unknown,studies have shown that it is closely related to a variety of factors,including the immune system,the environment,intestinal microecological balance,and genetics.Ferroptosis associated damage occurs in patients with UC and in models of UC,and is effectively alleviated with the use of ferroptosis inhibitors.Ferroptosis is a new form of regulatory cell death caused by iron overaccumulation and lipid peroxidation and is characterised by iron deposition,abnormal lipid peroxidation,and abnormal amino acid metabolism.This article reviews the three main features of ferroptosis to explore the mechanisms and strategies for the prevention and treatment of UC based on iron death.

关 键 词：铁死亡 溃疡性结肠炎 细胞死亡 

分 类 号：R574.62[医药卫生—消化系统]