CD155、TIGIT在胃肠神经内分泌肿瘤中的表达及与临床病理特征的关系  

Relationship between expression of CD155 and TIGIT and clinicopathological features in gastrointestinal neuroendocrine tumors

作　　者：谢伟 余松 侯能易[2] 严力 曹钦兴 旦真甲 袁兴梅 陆河江 刘杰 庞明辉 Wei Xie;Song Yu;Neng-Yi Hou;Li Yan;Qin-Xing Cao;Zhen-Jia Dan;Xing-Mei Yuan;He-Jiang Lu;Jie Liu;Ming-Hui Pang(School of Clinical Medicine,Southwest Medical University,Luzhou 646000,Sichuan Province,China;Department of Geriatric Surgery,Sichuan Academy of Medical Sciences&Sichuan Province People’s Hospital,Chengdu 610072,Sichuan Province,China;School of Medicine,University of Electronic Science and Technology,Chengdu 611731,Sichuan Province,China)

机构地区：[1]西南医科大学临床医学院,四川省泸州市646000 [2]四川省医学科学院•四川省人民医院老年综合外科,四川省成都市610072 [3]电子科技大学医学院,四川省成都市611731

出　　处：《世界华人消化杂志》2024年第2期123-133,共11页World Chinese Journal of Digestology

基　　金：四川省科技厅重点研发项目,No.2023YFS0185、No.2022YFS0220和No.2023YFS0197;四川省科技厅四川省自然科学基金,No.2022NSFSC1541;四川省卫生健康委员会,四川省干部保健科研项目,No.川干研2023-209和No.川干研2023-206;电子科技大学,电子科技大学-四川省人民医院“医工交叉联合基金”,No.ZYGX2021YGLH022.

摘　　要：背景胃肠神经内分泌肿瘤(gastrointestinal neuroendocrine neoplasms,GI-NENs)临床表现多样,部分具有高侵袭性及转移性,预后差.收集我院诊治的GI-NENs患者的临床病理资料,免疫组化检测CD155、T细胞免疫球蛋白和ITIM结构域蛋白(T cell immunoreceptor with Ig and ITIM domains,TIGIT)的表达量,探讨其与临床病理和预后的关系,为患者的治疗提供一个新的方向.目的探讨CD155、TIGIT在GI-NENs中的表达量与临床病理特征的关系.方法收集2016-11/2020-08经我院诊治的168例GI-NENs患者的临床病理资料.免疫组化检测CD155、TIGIT的表达量,探讨其与临床病理和预后的关系.结果CD155和TIGIT在病理分级高的GI-NENs组织中,表达量也较高,差异有统计学意义(P<0.05);CD155表达量与年龄、肿瘤位置、肿瘤最大直径、病理分级、T分期、淋巴结转移、远处转移、TNM分期、Ki-67指数有关(P<0.05);TIGIT表达量与肿瘤最大直径、病理分级、T分期、淋巴结转移、TNM分期、Ki-67指数有关(P<0.05);CD155和TIGIT表达量高的患者预后较表达量低者差,差异有统计学意义(P<0.05).结论CD155和TIGIT表达量在不同分级、分期的GI-NENs患者存在差异,可能参与了GI-NENs的发生及进展的调控过程,高表达可能提示预后不佳.BACKGROUND Gastrointestinal neuroendocrine neoplasms(GI-NENs)have various clinical manifestations,some of which are highly invasive and metastatic,with a poor prognosis.We collected the clinicopathologic data of GI-NENs patients treated at our hospital and detected the expression of CD155 and T cell immunoreceptor with Ig and ITIM domains(TIGIT)by immunohistochemistry to explore their relationship with clinicopathological characteristics and prognosis,in order to provide a new direction for the treatment of such patients.AIM To investigate the relationship between the expression of METHODS The clinicopathologic data of 168 patients with GI-NENs who were treated at our hospital from November 2016 to August 2020 were collected.Immunohistochemistry was used to detect the expression of CD155 and TIGIT,and their relationship with clinicopathological characteristics and prognosis was explored.RESULTS CD155 and TIGIT expression was significantly higher in GI-NENs tissues with high pathological grade(P<0.05).CD155 expression was correlated with age,tumor location,maximum tumor diameter,pathological grade,T stage,lymph node metastasis,distant metastasis,TNM stage,and Ki-67 index(P<0.05).TIGIT expression was correlated with maximum tumor diameter,pathological grade,T stage,lymph node metastasis,TNM stage,and Ki-67 index(P<0.05).The prognosis of patients with high CD155 and TIGIT expression was significantly poorer than that of patients with low expression(P<0.05).CONCLUSION CD155 and TIGIT expression differs in patients with GI-NENs of different grades and stages,and they may be involved in the occurrence and progression of GI-NENs.High expression of CD155 and TIGIT may suggest a poor prognosis in GI-NENs.

关 键 词：胃肠神经内分泌肿瘤 CD155 TIGIT 预后 

分 类 号：R735[医药卫生—肿瘤]