多烯磷脂酰胆碱联合阿托伐他汀对酒精性脂肪肝患者肝功能及血浆ET、血清TNF-α的影响  

The effect of polyene phosphatidylcholine combined with atorvastatin on liver function and plasma ET and serum TNF-αof patients with alcoholic fatty liver

作　　者：邓广旭 廖芬 何笑金 DENG Guang-xu;LIAO Fen;HE Xiao-jin(Department of Pharmacy,Zhongshan Triangle Hospital,Zhongshan 528400,China)

机构地区：[1]中山市三角医院药剂科,528400

出　　处：《中国现代药物应用》2024年第4期34-38,共5页Chinese Journal of Modern Drug Application

摘　　要：目的研究多烯磷脂酰胆碱(PPC)联合阿托伐他汀治疗酒精性脂肪肝(AFL)的效果及对患者肝功能指标、血浆内皮素(ET)、血清肿瘤坏死因子-α(TNF-α)的影响。方法98例AFL患者,随机抽取分为对照组及观察组,各49例。对照组给予PPC治疗,观察组给予PPC联合阿托伐他汀治疗。比较两组治疗前后的肝功能指标[丙氨酸氨基转移酶(ALT)、谷草转氨酶(AST)]、血脂指标[总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)]、炎性因子[C反应蛋白(CRP)、TNF-α]、血浆ET水平,临床效果,不良事件发生情况。结果两组治疗后的ALT、AST水平均比治疗前下降,且观察组ALT(44.75±6.36)U/L、AST(40.65±4.62)U/L明显低于对照组的(68.87±7.78)、(58.11±5.85)U/L(P<0.05)。两组治疗后的TG、TC、LDL-C水平均比治疗前下降,HDL-C水平比治疗前升高,且观察组TG(1.05±0.13)mmol/L、TC(3.07±0.66)mmol/L、LDL-C(1.79±0.35)mmol/L低于对照组的(1.77±0.22)、(4.32±0.75)、(2.49±0.47)mmol/L,HDL-C(1.40±0.14)mmol/L高于对照组的(1.05±0.09)mmol/L(P<0.05)。两组治疗后的CRP、TNF-α、ET水平均比治疗前下降,且观察组CRP(2.21±0.57)mg/L、TNF-α(247.76±12.08)pg/ml、ET(0.34±0.07)pg/ml明显低于对照组的(3.36±0.53)mg/L、(332.68±12.21)pg/ml、(0.79±0.13)pg/ml(P<0.05)。观察组治疗后总有效率95.92%明显高于对照组的83.67%(P<0.05)。两组不良事件发生率无统计学差异(P>0.05)。结论PPC联合阿托伐他汀治疗AFL的疗效确切,可有效降低炎症反应,改善血脂水平,保护肝功能,不良事件少,安全可靠。Objective To study the effect of polyene phosphatidylcholine(PPC)combined with atorvastatin on liver function and plasma endothelin(ET)and serum tumor necrosis factor-α(TNF-α)of patients with alcoholic fatty liver(AFL).Methods 98 AFL patients were randomly divided into a control group and an observation group,with 49 cases in each group.The control group was treated with polyene phosphatidylcholine,while the observation group was treated with PPC combined with atorvastatin.Comparison was made on liver function indicators[alanine aminotrasferase(ALT),aspartate transaminase(AST)],blood lipid indicators[total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides(TG)],inflammatory factors[C-reactive protein(CRP),TNF-α]and plasma ET before and after treatment,the clinical effects,and adverse drug reactions between the two groups.Results After treatment,the levels of ALT and AST in both groups decreased compared with those before treatment;and ALT of(44.75±6.36)and AST of(40.65±4.62)U/L in the observation group were significantly lower than(68.87±7.78)and(58.11±5.85)U/L in the control group(P<0.05).After treatment,the levels of TG,TC and LDL-C in both groups were lower than those before treatment,and the level of HDL-C was higher than that before treatment;the observation group had TG of(1.05±0.13)mmol/L,TC of(3.07±0.66)mmol/L and LDL-C of(1.79±0.35)mmol/L,which were lower than(1.77±0.22),(4.32±0.75)and(2.49±0.47)mmol/L in the control group;HDL-C of(1.40±0.14)mmol/L in the observation group was higher than(1.05±0.09)mmol/L in the control group(P<0.05).After treatment,the levels of CRP,TNF-αand ET in both groups decreased compared with those before treatment;the observation group had CRP of(2.21±0.57)mg/L,TNF-αof(247.76±12.08)pg/ml and ET of(0.34±0.07)pg/ml,which were significantly lower than(3.36±0.53)mg/L,(332.68±12.21)pg/ml and(0.79±0.13)pg/ml in the control group(P<0.05).After treatment,the total effective rate of 95.92%in the obse

关 键 词：多烯磷脂酰胆碱 阿托伐他汀 酒精性脂肪肝 肝功能 内皮素 炎性因子 不良事件 

分 类 号：R575.5[医药卫生—消化系统]