不同比例雌雄激素诱导大鼠前列腺炎症、纤维化的研究  

Study on the induction of prostatitis and fibrosis in rats by different ratios of estrogen and androgen

作　　者：王晓东[1] 张雪圆 田野[1] 王元林[1] 江克华 李凯[1] 王振 李涛 Wang Xiaodong;Zhang Xueyuan;Tian Ye;Wang Yuanlin;Jiang Kehua;Li Kai;Wang Zhen;Li Tao(Department of Urology,Guizhou Provincial People’s Hospital,Guiyang 550002,Guizhou,China;Department of Urology,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)

机构地区：[1]贵州省人民医院泌尿外科,贵州贵阳550002 [2]贵州医科大学附属医院泌尿外科,贵州贵阳550004

出　　处：《贵州医药》2024年第2期176-179,共4页Guizhou Medical Journal

基　　金：贵州省科技基金(黔科合基础-ZK[2021]378);地区科学基金项目(82160149)。

摘　　要：目的研究不同比例浓度雌雄激素对前列腺组织炎症、纤维化程度的影响。方法取4月龄SD雄性大鼠84只,随机分并对78只大鼠行双侧睾丸切除手术去势模型,同时对去势大鼠皮下注射不同浓度雌雄激素,1个月后取大鼠前列腺组织,通过HE染色和Masson染色分别观察前列腺炎症及纤维化程度。结果雌激素能诱导前列腺组织炎症浸润及纤维化,且随雌激素浓度增加而加重,而雄激素在一定程度上能缓解炎症、纤维化程度,其缓解程度与雄激素浓度比例正相关。结论雌激素能诱导前列腺组组织炎症、纤维化,雄激素能改善前列腺炎症及纤维化,其作用与浓度密切相关。Objective To investigate the effects of different concentrations of estrogen and androgen on the degree of inflammation and fibrosis in prostate tissue.Methods The total of 84 SD male rats for 4-month-old were randomly divided,and subjected to bilateral testicular resection surgery for castration in 78 rats.At the same time,different concentrations of estrogen and androgen were subcutaneously injected into the castrated rats.One month later,the prostate tissue of the rats was taken,and the degree of prostate inflammation and fibrosis were observed by HE staining and Masson staining,respectively.Results Estrogen can induce inflammation infiltration and fibrosis in prostate tissue,which worsens with the increase of estrogen concentration,while androgen can alleviate the degree of inflammation and fibrosis to a certain extent,and the degree of relief was positively correlated with the proportion of androgen concentration.Conclusion Estrogen can induce inflammation and fibrosis in prostate tissue,while androgen can improve prostatitis and fibrosis,and its effect is closely related to its concentration.

关 键 词：雌雄激素比例 前列腺纤维化 前列腺炎症 

分 类 号：R363[医药卫生—病理学]