光镍协同催化合成对甲氧基苯丙酮  

Photoredox/Nickel-Catalyzed Synthesis of 4′-Methoxypropiophenone

作　　者：郭镇宇 李雨杭 陈帅 朱成建[1] 谢劲 Zhenyu Guo;Yuhang Li;Shuai Chen;Chengjian Zhu;Jin Xie(School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China)

机构地区：[1]南京大学化学化工学院,南京210023

出　　处：《大学化学》2024年第1期210-217,共8页University Chemistry

基　　金：南京大学“千”层次优质课程建设;江苏省高等教育教学改革研究课题重中之重项目。

摘　　要：光-镍协同催化反应是一种新兴的合成方法,具有产率高、条件温和、适用范围广等多种优点。我们以可持续发展理念为出发点,利用常见的工业原料芳香羧酸化合物和乙烯在温和的反应条件下高效合成了高附加值的芳基酮类化合物。该反应是第一例在空气氛围下光镍协同催化的芳基羧酸和工业气体乙烯的反应。这种方法实现了资源高效利用,操作简单,易于学生掌握,填补了基础有机化学实验教学中光化学反应相关内容的空白,具有重要的应用价值和教学价值。The photo-nickel synergistic catalytic reaction emerges as a promising synthetic method,offering advantages such as high yields,mild reaction conditions,and broad scope.Guided by the principles of sustainable development,we have successfully synthesized valued aromatic ketone derivatives utilizing prevalent industrial feedstocks,aromatic carboxylic acids and ethylene under mild reaction conditions.It would be the first example of photo-nickel synergistic catalyzed reaction between aromatic acids and ethylene under air atmosphere.This synthetic method features in a high efficiency utilization of resource,simple operation and easy access for the students to grasp.This approach not only bridges a knowledge gap in teaching photochemical reactions within foundational organic chemistry experiments but also holds substantial practical and pedagogical merit.

关 键 词：可见光催化 镍催化 芳基酮类化合物 有机化学实验 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]