综合有机合成实验苯佐卡因的课程思政设计  

Design of Course Ideology and Politics for the Comprehensive Organic Synthesis Experiment of Benzocaine

作　　者：沙风 伍新燕[1] 胡坪[1] 张文清[1] 栾晓洋 马云飞[1] Feng Sha;Xinyan Wu;Ping Hu;Wenqing Zhang;Xiaoyang Luan;Yunfei Ma(School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China.)

机构地区：[1]华东理工大学化学与分子工程学院,上海200237

出　　处：《大学化学》2024年第2期110-115,共6页University Chemistry

基　　金：上海高校课程思政领航计划(重点改革领航学院);化学类专业基础课程思政建设与实践(H20200507);华东理工大学教师思政和师德建设研究课题(YJ0109004);化学实验教学改革研究虚拟教研室;工科化学基础课程虚拟教研室;有机化学虚拟教研室。

摘　　要：将传统的合成路线和条件都给定的综合有机实验“苯佐卡因的合成”,改造成路线可设计、条件可优化的创新性实验。学生通过文献调研、综合分析以及评估合成策略和具体实验条件,提出兼顾宏观(路线)和微观(具体条件)的改进实验方案,规避原实验的局限性和不足。根据学生专业和培养方案的不同,开放部分或全部“权限”给学生,从不同层级原料出发,设计绿色、高效的合成路线,确定具体的实验方案;或根据建议路线,调整和优化实验条件,使学生在得到基础实验操作技能训练的基础上,其绿色、高效、可持续发展的合成理念也得到进一步升华。鼓励学生运用科学思维,将学科前沿成果引入实验实践中,培养学生科学创新能力。引导学生从全局出发,提升团队合作意识和能力。In this paper,the classic comprehensive organic synthesis experiment course,the synthesis of Benzocaine,has been redesigned and upgraded to an innovative experiment allowing for route design and condition optimization.Students are encouraged to conduct literature research,undertake comprehensive analyses,and evaluate synthesis strategies and specific experimental conditions.They are then tasked with proposing an experimental scheme that balances both macro(route)and micro(specific conditions)perspectives,overcoming the limitations and deficiencies of the original experiment.Depending on the students’majors and training programs,certain or all“permissions”are granted for students,which enables students to start with different raw materials,design environmentally-friendly and efficient synthesis routes,determine specific experimental plans,and optimize the experimental conditions based on the model route.Beyond gaining foundational experimental operation skills,students embrace a heightened philosophy of green,efficient,and sustainable synthesis.The approach urges students to apply scientific thinking,incorporating cutting-edge academic achievements into experimental practices,thereby nurturing their scientific innovation capabilities.It also guides students to adopt a holistic perspective,enhancing their awareness of and capabilities in team collaboration.

关 键 词：苯佐卡因 合成路线设计 反应条件优化 绿色合成 课程思政 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]