基于肠道菌群探讨从脾虚论治糖尿病便秘  

Treatment of Diabetic Constipation from Spleen Deficiency Based on Intestinal Flora

作　　者：任静[1,2] 李宇思 李会敏 方泽阳 魏军平 REN Jing;LI Yu-si;LHui-min;FANG Ze-yang;WEI Jun-ping(Bejing University of Chinese Medicine,Beijing 100029;Department of Endocrinology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053)

机构地区：[1]北京中医药大学,北京100029 [2]中国中医科学院广安门医院内分泌科,北京100053

出　　处：《世界中西医结合杂志》2024年第2期399-403,414,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：中国中医科学院科技创新工程项目(CI2021A01617);中国中医科学院中医药循证能力建设项目(60104);北京市中医药科技发展资金项目(JCZX-2020-09)。

摘　　要：糖尿病(Diabetes mellitus, DM)作为四大慢病之一严重影响人类健康,其流行趋势十分严峻。而糖尿病便秘作为临床常见的糖尿病并发症之一,具有普发性,极大的影响患者的生活质量。现代研究发现肠道菌群与糖尿病便秘有着密不可分的关系,且肠道菌群与中医“脾”生理相通,病理相关。从脾虚论治糖尿病便秘的中医药疗法能够调节肠道菌群并可取得良好的治疗效果。文中结合中医理论与现代医学认识,基于肠道菌群、脾虚、糖尿病便秘三者之间的相关性,从肠道菌群角度探讨从脾虚论治糖尿病便秘,为糖尿病便秘的防治提供新的思路。Diabetes mellitus(DM),as one of the four major chronic diseases,severely affects human health with a concerning prevalence trend.Diabetic constipation,a common complication of DM,is prevalent and significantly diminishes the quality of life of patients.Recent studies have uncovered a strong link between intestinal flora and diabetic constipation,and this connection is consistent with the physiological and pathological concepts of the spleen in traditional Chinese medicine(TCM).TCM methods for diabetic constipation from the perspective of spleen deficiency can effectively regulate the intestinal flora and yield positive therapeutic outcomes.This paper,by integrating TCM theory with modern medical insights and examining the interplay among the intestinal flora,spleen deficiency,and diabetic constipation,explored the treatment of diabetic constipation from the angle of spleen deficiency and intestinal flora.The discussion aimed to offer novel strategies for the prevention and management of diabetic constipation.

关 键 词：糖尿病便秘 肠道菌群 脾虚 理论探讨 

分 类 号：R781.64[医药卫生—口腔医学] R256.35[医药卫生—临床医学]