乳腺癌患者血清GP73、miR-27a水平的变化及其与临床病理、化疗疗效的相关性  

Changes of serum GP73 and miR-27a levels in patients with breast cancer and their correlation with clinicopathology and chemotherapy efficacy

作　　者：陆佳团 王征[1] 张浩[1] 唐梦雨 LU Jia-tuan;WANG Zheng;ZHANG Hao;TANG Meng-yu(Ward No.1,Breast Department,Nanyang Central Hospital,Nanyang 473200,Henan,CHINA)

机构地区：[1]南阳市中心医院乳腺科一病区,河南南阳473200

出　　处：《海南医学》2024年第5期689-693,共5页Hainan Medical Journal

基　　金：河南省科技攻关计划项目(编号:222102310474)。

摘　　要：目的 分析乳腺癌患者血清高尔基体蛋白73 (GP73)、微小RNA-27a (miR-27a)水平变化及其与临床病理特征、化疗疗效的相关性。方法 选取2021年10月至2023年1月南阳市中心医院收治的80例乳腺癌患者作为研究组,另选取同期健康女性志愿者80例作为对照组。比较两组受检者以及研究组不同临床病理特征患者的血清GP73、miR-27a水平,并比较研究组不同化疗疗效患者化疗前后的血清GP73、miR-27a水平及变化值(△GP73、△miR-27a),采用Spearman相关法分析化疗前血清GP73、miR-27a水平与临床病理特征相关性,以及△GP73、△miR-27a与化疗疗效的相关性。结果 研究组患者的血清GP73、miR-27a水平分别为(121.35±40.12) ng/L、0.71±0.20,明显高于对照组的(47.68±15.29) ng/L、0.21±0.07,差异均有统计学意义(P<0.05);研究组患者中,不同临床分期、分化程度、肿瘤直径、淋巴结转移患者血清GP73、miR-27a水平比较差异均有统计学意义(P<0.05);经Spearman相关法分析结果显示,研究组血清GP73、miR-27a水平与乳腺癌临床分期、肿瘤直径、淋巴结转移呈正相关(P<0.05),与分化程度呈负相关(P<0.05);无效者化疗前后的血清GP73、miR-27a水平明显高于有效者,差异均有统计学意义(P<0.05);无效者△GP73、△miR-27a分别为13.52±3.16、0.07±0.02,明显低于有效者的21.31±5.42、0.12±0.03,差异均有统计学意义(P<0.05);经Spearman相关法分析结果显示,△GP73、△miR-27a与化疗疗效呈正相关(r=0.658、0.714,P<0.05)。结论 血清GP73、miR-27a水平与乳腺癌临床病理特征、化疗疗效密切相关,可以作为评估病情进展及化疗疗效的潜在指标。Objective To analyze the changes of serum Golgi protein 73(GP73) and microRNA-27a(miR-27a) levels in patients with breast cancer and their correlation with clinicopathological characteristics and chemotherapy efficacy.Methods Eighty breast cancer patients admitted to Nanyang Central Hospital from October 2021 to January 2023 were selected as the study group,and 80 healthy female volunteers in the same period were selected as the control group.The serum GP73 and miR-27a levels were compared between the two groups of subjects and among patients with different clinical and pathological characteristics in the study group.The serum GP73 and miR-27a levels and changes before and after chemotherapy were compared among patients with different chemotherapy efficacy in the study group(△GP73,△miR-27a).Spearman correlation method was used to analyze the correlation between serum GP73and miR-27a levels before chemotherapy and clinical and pathological characteristics,as well as the correlation between△GP73,△miR-27a and chemotherapy efficacy.Results The serum GP73 and miR-27a levels of patients in the study group were(121.35±40.12) ng/L and 0.71±0.20,respectively,significantly higher than(47.68±15.29) ng/L and 0.21±0.07 in the control group(P<0.05).Among the patients in the study group,there were significant differences in the levels of serum GP73 and miR-27a among patients with different clinical stages,differentiation degrees,tumor diameters,and lymph node metastasis(P<0.05).Spearman correlation analysis showed that serum GP73 and miR-27a levels in the study group were positively correlated with the clinical stage,tumor diameter,and lymph node metastasis of breast cancer(P<0.05),and negatively correlated with the degree of differentiation(P<0.05).The serum GP73 and miR-27a levels of ineffective patients before and after chemotherapy were significantly higher than those of effective patients,and the differences were statistically significant(P<0.05).The values of △GP73 and △miR-27a in the ineffective group wer

关 键 词：乳腺癌 高尔基体蛋白73 微小RNA-27a 化疗 疗效 相关性 

分 类 号：R737.9[医药卫生—肿瘤]