植物化学物γ-生育三烯酚抗癌活性与作用机制的研究进展  

Research progress on the anticancer activity and mechanism of phytochemical - gamma-tocotrienol

作　　者：朱昊 王发琳 孙文广(综述) 刘家仁(审校)[1] ZHU Hao;WANG Falin;SUN Wenguang;LIU Jiaren(Department of Clinical Laboratory,The Forth Affiliated Hospital of Harbin Medical University,Harbin 150001,China;International Peace Maternity and Child Health Hospital,Shanghai Jiao Tong University School of Medicine)

机构地区：[1]哈尔滨医科大学附属第四医院检验科,哈尔滨150001 [2]上海交通大学医学院国际和平妇幼保健院

出　　处：《实用肿瘤学杂志》2023年第6期485-490,共6页Practical Oncology Journal

基　　金：国家自然科学基金项目(编号:81273061)。

摘　　要：γ-生育三烯酚(γ-Tocotrienol,γ-T3)是一种常见的植物化学物,属于天然维生素E中一大亚类,主要来源是棕榈油和米糠。与饱和性生育酚(TOC)相比,γ-T3侧链含有不饱和键,并形成异戊二烯链。γ-T3对多种慢性疾病具有治疗活性,尤其在抑制肿瘤增殖和侵袭方面具有广泛的应用潜力。随着研究的深入,越来越多证据表明γ-T3在抑制癌细胞迁徙和转移、诱导肿瘤细胞凋亡、阻滞细胞周期和调节癌症相关信号通路等方面发挥着重要的作用。因此,本文将对γ-T3的抑癌作用与机制进行综述。γ-Tocotrienol(γ-T3)is a common phytochemical belonging to a major subclass of natural vitamin E,mainly derived from palm oil and rice bran.Compared to saturated tocopherol(TOC),theγ-T3 side chain contains unsaturated bonds and forms isoprene chains.γ-T3 has therapeutic activity for various chronic diseases with broad potential applications,especially in inhibiting tumor proliferation and invasion.With deeply research,more and more evidence suggests thatγ-T3 plays an important role in inhibiting cancer cell migration and metastasis,inducing tumor cell apoptosis,arresting cell cycle and regulating cancer-related signaling pathways.Therefore,this article will review the anti-cancer effects and mechanisms ofγ-T3.

关 键 词：γ-生育三烯酚 抑癌活性 植物化学物 

分 类 号：R73[医药卫生—肿瘤]