Agrin参与恶性肿瘤发生发展的研究现状  

Research status of Agrin involvement in the occurrence and development of malignant tumors

作　　者：赵世博 陈永峰 黎惠怡(综述) 符爱珍(审校) ZHAO Shibo;CHEN Yongfeng;LI Huiyi;FU Aizhen(Department of Obstetrics and Gynecology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China)

机构地区：[1]广东医科大学附属医院妇产科,湛江524000

出　　处：《实用肿瘤学杂志》2023年第6期507-512,共6页Practical Oncology Journal

基　　金：湛江市科技发展专项资金竞争性分配项目(编号:220826174543328)。

摘　　要：恶性肿瘤已成为威胁人类健康的第一大疾病,全球恶性肿瘤发病率逐年上升,目前晚期和复发患者生存质量差和耐药的问题愈加明显。减少肿瘤的侵袭与转移、提高肿瘤患者的生存及预后是肿瘤治疗中亟待解决的难题。集聚蛋白(Agrin)是一种与神经突触形成相关的膜蛋白,近年来的研究证实Agrin在肿瘤发生发展中发挥着重要的作用。Agrin表达于恶性肿瘤和免疫细胞中,在肿瘤血管生成、细胞增殖、迁移、化疗耐药和中性粒细胞浸润中发挥着重要的调控作用。本文就Agrin的研究现状,特别是其在恶性肿瘤发生发展中的相关作用及机制进行总结与分析。Malignant tumor has become the largest disease threatening human health.The global incidence of cancer is increasing year by year.At present,the poor quality of life and drug resistance of patients with advanced and recurrent cancer are becoming increasingly obvious.Reducing the invasion and metastasis of tumor,improving the survival and prognosis of tumor patients,are urgent problems to be solved in tumor treatment.Agrin is a membrane protein associated with synaptic formation,and recent studies have shown that Agrin plays an important role in the occurrence and development of tumors.Agrin is expressed in malignant tumors and immune cells,playing an important regulatory role in tumor angiogenesis,cell proliferation and migration,chemotherapy resistance,and neutrophil infiltration.This article summarizes and analyzes the current research status of Agrin,especially its related role and mechanism in the occurrence and development of malignant tumors.

关 键 词：集聚蛋白 恶性肿瘤 信号通路 

分 类 号：R730.2[医药卫生—肿瘤]