帕金森病患者的语音声学特征分析  

Study of Voice Acoustic Characteristics in Patients with Parkinson's Disease

作　　者：文鹏程 张峪涵 文贵华[3] Wen Pengcheng;Zhang Yuhan;Wen Guihua(Department of Information Security,Hubei University for Nationalities,Enshi,444500,China;不详)

机构地区：[1]湖北民族学院,恩施444500 [2]东莞市松山湖中心医院神经内科 [3]华南理工大学

出　　处：《听力学及言语疾病杂志》2024年第2期134-138,共5页Journal of Audiology and Speech Pathology

基　　金：广东省医学科研基金项目(B2021446);东莞市社会发展重点项目(202050715024222)资助。

摘　　要：目的 分析帕金森病(PD)患者的语音声学特征,初步探索声学指标与PD的相关性。方法 共纳入2021年1月至2022年1月于东莞市松山湖中心医院确诊的PD患者83例作为PD组,健康体检者87例作为正常对照组。对帕金森病患者根据统一帕金森病综合评分量表(unified Parkinson’s disease rating scale,UPDRS)进行评估。采集所有研究对象的声音样本,利用语音处理软件提取声学特征指标。按照性别分组比较研究对象的声学特征指标,并分析PD患者声学特征指标与UPDRS评分的相关性。结果 共收集受试者语音样本3 720个,其中PD组1 895个,对照组1 825个。PD组的最大基频、基频范围及基频周期变化率低于正常对照组,振幅扰动高于正常对照组,差异均有统计学意义(均为P<0.05)。女性PD患者基频周期变化率与UPDRS-Ⅲ评分呈负相关(r=-0.617,P<0.05)。结论 PD患者语音声学变化主要表现为最大基频、基频范围及基频周期变化率降低,振幅扰动增高;基频周期变化率可能用于协助评估女性PD患者病情变化。Objective To analyze the voice acoustic characteristics in Parkinson's disease(PD) patients,and to study the correlation between voice features and the severity of disease.Methods A total of 83 patients with PD were selected from the Dongguan Songshan Lake Central Hospital from January 2021 to January 2022 as the experimental group,and 87 healthy subjects were enrolled as the control group.All the PD patients were tested with Unified Parkinson's Disease Rating Scale(UPDRS).The vioce samples of all subjects were collected and acoustic characteristic were analyzed using speech processing software.The acoustic parameters of two groups were compared according to sex,and the correlation between vioce features and the severity of disease was analyzed.Results A total of 3 720 speech samples were collected,including 1 895 for PD and 1 825 for the controls.The maximum fundamental frequency,fundamental frequency range and fundamental frequency period change rate were lower than the control group,and the amplitude disturbance was higher than the control group,the differences were statistically significant(P<0.05).There was a negative correlation between UPDRS-Ⅲ score and the rate of fundamental frequency period change in female patients with PD(r=-0.617,P<0.05).Conclusion The changes in acoustic parameters are mainly manifested as the decrease in the maximum fundamental frequency,range of fundamental frequency and the change rate of fundamental frequency period,and the increase in the the amplitude disturbance.The rate of fundamental frequency period change may be used as an indicator to evaluate the severity in female patients with PD.

关 键 词：帕金森病 语音障碍 言语声学 

分 类 号：R742.5[医药卫生—神经病学与精神病学]