迟发性运动障碍的诊疗研究进展  

Research progress in diagnosis and treatment of tardive dyskinesia

作　　者：袁俊亮 谭云龙[2] 王强[3] 石川[1] 王刚[4] 吴仁容[5] 胡少华[6] 万新华[7] 刘铁榜[8] 商慧芳[9] 陈海波[10] 司天梅[1] 于欣[1] Yuan Junliang;Tan Yunlong;Wang Qiang;Shi Chuan;Wang Gang;Wu Renrong;Hu Shaohua;Wan Xinhua;Liu Tiebang;Shang Huifang;Chen Haibo;Si Tianmei;Yu Xin(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100191,China;Beijing Huilongguan Hospital,Peking University Huilongguan Clinical Medical School,Beijing 100096,China;Mental Health Center,West China Hospital of Sichuan University,Chengdu 610041,China;The National Clinical Research Center for Mental Disorders,Beijing Anding Hospital Affiliated to Capital Medical University,Beijing 100088,China;The Second Xiangya Hospital of Central South University,Changsha 410011,China;The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Shenzhen Kang Ning Hospital,Shenzhen 518000,China;Department of Neurology,West China Hospital of Sichuan University,Chengdu 610041,China;Department of Neurology,National Center of Gerontology,Beijing Hospital,Beijing 100730,China)

机构地区：[1]北京大学第六医院、北京大学精神卫生研究所、国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100191 [2]北京回龙观医院、北京大学回龙观临床医学院,北京100096 [3]四川大学华西医院心理卫生中心,成都610041 [4]首都医科大学附属北京安定医院、国家精神心理疾病临床医学研究中心、精神疾病诊断与治疗北京市重点实验室,北京100088 [5]中南大学湘雅二医院,长沙410011 [6]浙江大学医学院附属第一医院,杭州310003 [7]中国医学科学院北京协和医院,北京100730 [8]深圳市康宁医院、深圳市精神卫生中心,深圳518000 [9]四川大学华西医院神经内科,成都610041 [10]北京医院神经内科、国家老年医学中心、中国医学科学院老年医学研究院,北京100730

出　　处：《中华精神科杂志》2024年第2期121-128,共8页Chinese Journal of Psychiatry

摘　　要：迟发性运动障碍(tardive dyskinesia,TD)是药物诱发的多动性运动障碍,一般表现为舌、下面部和下颌以及四肢不自主痉挛或舞蹈样运动(至少持续数周),发生在使用神经阻滞剂类药物至少数月后,对神经系统的损伤不可逆,显著影响患者的功能预后。本文综述了近年来关于TD相关危险因素和可能的发病机制、临床特征、评估识别及治疗管理等最新研究进展,以期提高专业人员对TD的认识,实现早期预防和识别,规范治疗,改善患者的预后和生活质量。Tardive dyskinesia(TD)is a medication-induced hyperkinetic movement disorder,generally manifested as involuntary spasms or choreiform movements of the tongue,lower face and jaw,and limbs(lasting at least several weeks).It occurs after using neuroleptic medication for at least several months,causing irreversible injuries to the nerve system and significantly impacting patients′daily function.This review summarizes recent research progress regarding TD risk factors,possible pathogenesis,clinical characteristics,assessment and identification,and treatment and management approaches.The goal is to raise awareness of TD to archive early prevention and identification,standardize treatment,and improve patients′prognosis and quality of life.

关 键 词：运动障碍 药物性 迟发性运动障碍 迟发性综合征 锥体外系不良反应 药物源性帕金森综合征 

分 类 号：R744.8[医药卫生—神经病学与精神病学]