血清7种肺癌相关自身抗体检测在肺部磨玻璃结节良恶性诊断中的价值  

Serum levels of seven lung cancer-related autoantibodies in differential diagnosis of benign and malignant lung groundglass nodules

作　　者：王强 林善安 王晓军 WANG Qiang;LIN Shanan;WANG Xiaojun(Department of Thoracic Surgery,Taizhou Central Hospital,Taizhou 318000,China)

机构地区：[1]台州市中心医院心胸外科,318000

出　　处：《浙江医学》2024年第3期323-327,共5页Zhejiang Medical Journal

摘　　要：目的探讨血清7种肺癌相关自身抗体(7-AABs)检测在肺部磨玻璃结节(GGN)良恶性诊断中的价值。方法选取2022年5月至2023年7月台州市中心医院收治的89例肺部GGN患者为研究对象。根据病理学诊断结果分为肺癌(肺癌组)68例和良性GGN(良性GGN组)21例,比较两组患者血清7-AABs、癌胚抗原(CEA)及鳞癌抗原(SCC)水平,采用ROC曲线分析7-AABs、CEA、SCC单独或联合检测对GGN良恶性的诊断效能。结果肺癌组与良性GGN组患者血清7-AABs、CEA及SCC水平比较,差异均无统计学意义(均P>0.05)。7-AABs、CEA、SCC单独检测诊断GGN良恶性的AUC分别为0.627、0.534和0.513;7-AABs+CEA、7-AABs+SCC、7-AABs+CEA+SCC、7-AABs+CEA+SCC+性别+年龄+吸烟联合检测诊断GGN良恶性的AUC分别为0.657、0.631、0.667、0.703。结论血清7-AABs联合CEA、SCC、性别、年龄、吸烟检测可提高恶性GGN的检出率。Objective To investigate the value of serum seven lung cancer-related autoantibodies(7-AABs)in differential diagnosis of benign and malignant lung ground-glass nodules(GGN).Methods A total of 89 patients with pulmonary GGN admitted to Taizhou Central Hospital from May 2022 to July 2023 were enrolled in the study,including 68 cases of lung cancer(lung cancer group)and 21 cases of benign GGN(benign GGN group)according to the pathological diagnosis.Serum levels of 7-AABs,carcinoembryonic antigen(CEA)and squamous cell carcinoma antigen(SCC)were compared between the two groups.The ROC curve was used to analyze the diagnostic efficacy of 7-AABs,CEA and SCC or in combination for differentiating between benign and malignant GGN.Results There were no significant differences in serum levels of 7-AABs,CEA and SCC between lung cancer group and benign GGN group(all P>0.05).The AUC of 7-AABs,CEA and SCC for differential diagnosis of benign and malignant GGN were 0.627,0.534 and 0.513,respectively.The AUC of 7-AABs+CEA,7-AABs+SCC,7-AABs+CEA+SCC,7-AABs+CEA+SCC,7-AABs+CEA+SCC+gender+age+smoking was 0.657,0.631,0.667,0.703,respectively.Conclusion Serum 7-AABs combined with CEA,SCC,gender,age,and smoking history may improve the differentiating ability between benign of malignant GGN.

关 键 词：7种肺癌相关自身抗体 肺癌 磨玻璃结节 早期筛查 

分 类 号：R734.2[医药卫生—肿瘤]