灯芪通脉颗粒高效液相色谱法指纹图谱研究  

Study of High Performance Liquid Chromatography Fingerprint of Deng-Qi-Tong-Mai Granule

作　　者：台晶杰 甄会贤 张凤 王小露 张虹 Tai Jing-jie;Zhen Hui-xian;Zhang Feng;Wang Xiao-lou;Zhang Hong(ShanXi Pharmaceutical Vocational College,Taiyuan 030031,China)

机构地区：[1]山西药科职业学院,山西太原030031

出　　处：《北方药学》2024年第1期5-8,共4页Journal of North Pharmacy

摘　　要：目的:建立灯芪通脉颗粒的指纹图谱法,指认共有成分并评价质量。方法:使用Diamonsil C18色谱柱(4.6 mm×250 mm,5μm),流动相为水(含0.1%磷酸)-乙腈,梯度洗脱,检测波长为230nm。对10批灯芪通脉颗粒指纹图谱分析,并建立共有模式计算样品间的相似度。结果:样品具有较高的相似性。结论:本方法可用于评价灯芪通脉颗粒质量。Objective:To establish a fingerprinting method of Deng-Qi-Tong-Mai Granule for identifying common components and evaluating the quality.Method:The Diamonsil C18 chromatographic column(4.6 mm×250 mm,5μm)was used with a mobile phase consisting of water(containing 0.1%phosphoric acid)and acetonitrile in a gradient elution mode,with a detection wavelength of 230 nm.Fingerprint analysis was conducted on ten batches of Deng-Qi-Tong-Mai Granule,and a common pattern was established to calculate the similarity between the samples.Results:The samples exhibited high similarity.Conclusion:This fingerprinting method can be used to evaluate the quality of Deng-Qi-Tong-Mai Granule.

关 键 词：指纹图谱 高效液相色谱 灯芪通脉颗粒 质量评价 

分 类 号：R-331[医药卫生]