Tumor microenvironment-activated theranostic nanoreactor for NIR-II Photoacoustic imaging-guided tumor-specific photothermal therapy  

作　　者：Nan Yang Hui Li Changyu Cao Lei Zhao Xuejiao Song Wenjun Wang Wenjing Xu Yewei Zhang Peng Chen Xiaochen Dong 

机构地区：[1]Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM),School of Physical and Mathematical Sciences,Nanjing Tech University(NanjingTech),Nanjing 211816,China [2]School of Physical Science and Information Technology,Liaocheng University,Liaocheng 252059,China [3]Department of Hepatobiliary and Pancreatic Surgery,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China [4]School of Chemical and Biomedical Engineering,Lee Kong Chian School of Medicine,Nanyang Technological University,62 Nanyang Drive,Singapore 637459,Singapore

出　　处：《Fundamental Research》2024年第1期178-187,共10页自然科学基础研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(62120106002,51803091,61935004,22175089);Jiangsu Province Policy Guidance Plan(BZ2019014);Jiangsu Provincial key research and development plan(BE2021711);Natural Science Foundation of Shandong Province(ZR2020KB018);Taishan scholars construction special fund of Shandong Province,Natural Science Foundation of Ningbo(202003N40448);the Jiangsu postgraduate research innovation program(KYCX21_1103).

摘　　要：Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment(TME)have recently attracted considerable attention.In this study,TME-activatable 3,3′,5,5′-tetramethylbenzidine(TMB)-copper peroxide(CuO_(2))@poly(lactic-co-glycolic acid)(PLGA)@red blood cell membrane(RBCM)(TCPR)nanoparticles(NPs)for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO_(2)NPs and TMB into PLGA camouflaged by RBCMs.As an efficient H_(2)O_(2)supplier,once exposed to a proton-rich TME,CuO_(2)NPs can generate H_(2)O_(2)and Cu^(2+),which are further reduced to Cu^(+) by endogenous glutathione.Subsequently,the Cu^(+)-mediated Fenton-like reaction produces cytotoxic·OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal effects.Combined with the RBCM modification-prolonged blood circulation,TCPR NPs display excellent specificity and efficiency in suppressing tumor growth,paving the way for more accurate,safe,and efficient cancer theranostics.

关 键 词：Nanoparticles Photoacoustic imaging Second near-infrared region Tumor microenvironment Self-sufficient H_(2)O_(2) 

分 类 号：R730.5[医药卫生—肿瘤]