膜联蛋白A家族成员在乳腺癌中作用机制的研究进展  

Research progress on the mechanism of annexin A family members in breast cancer

作　　者：南璐 郭梦杰 高雅楠 贾红燕[2] NAN Lu;GUO Menjie;GAO Yanan;JIA Hongyan(The First Clinical College of Medicine,Shanxi Medical University,Taiyuan 030001;Department of Breast,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]山西医科大学第一医院乳腺科,山西太原030001

出　　处：《基础医学与临床》2024年第3期393-397,共5页Basic and Clinical Medicine

基　　金：山西省留学人员科技活动择优资助项目(20200036);山西省自然科学基金(201901D111347)。

摘　　要：膜联蛋白(ANX)家族广泛存在于细胞膜、细胞质或细胞外基质中。作为肿瘤的关键调控分子,膜联蛋白A(ANX A)家族可以通过影响细胞膜和细胞骨架的形成及参与信号通路,促进或抑制乳腺癌细胞的侵袭与转移。在细胞凋亡方面,ANX A家族通过参与促凋亡蛋白质和细胞周期独立激酶(CDKs)及相关通路的调节,在乳腺癌细胞凋亡中发挥作用。此外,ANX A家族还可以促进大量药物的治疗耐药。例如,ANX A1通过诱导上皮细胞-间质转化增强三阴性乳腺癌耐药,ANX A4通过形成ANX A4-Fhit复合物产生耐药性,含有ANX A6的外泌体的分泌以YAP1依赖的方式促进乳腺癌细胞的紫杉醇耐药。ANX A家族可能成为乳腺癌治疗的新靶点。The annexins(ANX)family is widely present in the cell membrane,cytoplasm or extracellular matrix.As key tumor regulatory molecules,annexins A(ANX A)family can promote or inhibit invasion and metastasis of breast cancer cells by influencing cell membrane and cytoskeleton formation and participating in signaling pathways.ANX A family also plays a role in the apoptosis of breast cancer cells by regulation of pro-apoptotic proteins and cell cycle independent kinases(CDKs)and related pathways.In addition,ANX A family can also promote therapeutic resistance to a large number of drugs.For instance,ANX A1 enhances triple-negative breast cancer resistance by inducing epithelial-mesenchymal transformation.ANX A4 induces resistance by forming ANX A4-Fhit complexes and secretion of exosomes containing ANX A6 promotes paclitaxel resistance in breast cancer cells in a YAP1-dependent manner.So ANX A family may be a new target for breast cancer treatment.

关 键 词：膜联蛋白A家族 乳腺癌 肿瘤发生 

分 类 号：R73[医药卫生—肿瘤]